Mechanisms of Thiols and Thiocarbamides Activities in the Physiological Environment

国家科学基金会化学部的化学催化项目支持波特兰州立大学的Reuben Simoyi教授研究与药物开发相关的新型有机硫化合物的机制和代谢物化学。 本工作的目标是合成几个系列的药物相关的硫脲衍生物，沿着与其他有机硫化合物，并评估它们的代谢活化和所得代谢产物的反应性。 许多新药含有有机硫部分，这项工作将有助于建立更深层次的机制理解和量化系统的协议，以评估其生理反应。这项研究的更广泛的影响包括其真正的跨学科性质，将合成与分析方法相结合，以研究一类重要的生物活性分子。 Simoyi教授在本科研究人员和他实验室中代表性不足的群体的科学家的培训方面有着出色的记录。 这项工作将通过促进活性化合物作为潜在药物的成功预测对制药行业产生转化影响。

The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Reuben Simoyi of Portland State University for investigation of mechanisms and metabolite chemistry of novel organsulfur compounds as related to drug development. The goal of this work is to synthesize several series of drug-related thiourea derivatives, along with other organosulfur compounds, and evaluate both their metabolic activations and the reactivity of the resulting metabolites. Many new drugs contain organosulfur moieties and this work will help establish a deeper mechanistic understanding and quantify systematic protocols to assess their physiological response. Broader impacts of this research include its true interdisciplinary nature, blending synthesis with analytical methods to study an important class of biologically active molecules. Professor Simoyi has an outstanding track record with undergraduate researchers and in the training of scientists from underrepresented groups in his laboratory. This work will have a translational impact on the pharmaceutical industry by facilitating successful predictions of active compounds as potential drugs.