SBIR Phase II: 4-Dimensional Optical Tissue Imaging by Variable Digital Illumination

这个小型企业创新研究(SBIR)第二阶段项目的主要目标是开发移动生理光学成像硬件和软件系统，使临床医生能够部署、捕获、评估和分发符合标准的图像数据，以表征深度伤口和心血管疾病。移动系统将使临床医生能够快速识别隐藏的伤口状况或有问题的血流模式的存在，从而使护理机构能够为他们的患者提供更具成本效益和知情的护理，同时将与创伤相关的医院获得性状况相关的经济损失降至最低。该项目的学术价值在于其科学追求，即定义、开发和分发一个全面的系统平台，该平台将显著加快向市场部署合适的生理光学成像解决方案。研究包括将照明模式与生理条件联系起来，同时通过数字信号处理的方式实现映射传递函数。研究目标包括系统定义、集成、算法优化和临床验证。该项目的更广泛的影响/商业潜力是提供相当负担得起的非侵入性成像工具，这些工具可用于帮助偏远地区的人或那些有经济劣势的人更容易获得治疗。这种便携式设备提高了合格临床医生远程获取患者伤口护理成像诊断的能力，提高了护理质量和社会可获得性。更广泛的商业好处包括，由于更彻底的伤口评估和更容易获得的机会，减少了就诊和住院时间。移动系统将使护理决策与基础组织和相关血流动力学的状态更紧密地结合在一起。它还将使临床医生和患者能够更有效地监测护理决策的好处。这种新颖且经济实惠的光学系统的开发有助于临床和生理上有意义的信息的成像，这将填补医学成像行业的一个空白，即能够提供对伤口护理至关重要的生理过程的定量可视化的护理点解决方案。移动成像技术的发展将增进对光学组织图像测绘、光电照明系统、图像处理、临床适用性和实时成像场景等领域的科学技术理解。

This Small Business Innovation Research (SBIR) Phase II project has as its main objective the development of a mobile physiological optical imaging hardware and software system to empower clinicians with the ability to deploy, capture, assess and distribute standards compliant image data characterizing deep wounds and cardiovascular conditions. The mobile system will allow clinicians to rapidly identify the presence of hidden wound conditions or problematic blood flow patterns thus allowing care facilities to provide more cost effective and informed care to their patients, while minimizing financial losses associated with wound related hospital acquired conditions. The intellectual merit of this project lies in its scientific pursuit to define, develop, and distribute a comprehensive systems platform that will significantly accelerate the deployment of suitable physiological optical imaging solutions into the market. The research includes linking illumination patterns to physiological conditions while implementing mapping transfer functions by way of digital signal processing. The research objectives include system definition, integration, algorithmic optimization, and clinical validations. The broader impact/commercial potential of this project is to provide substantially affordable noninvasive imaging tools that may be used to assist in treatments that are more accessible to persons in remote areas or those having economic disadvantages. The portable device increases the ability of qualified clinicians to access patient wound care imaging diagnostics remotely, improving quality of care and accessibility to society. Broader commercial benefits include reductions in hospital visits and stays due to more thorough wound assessments and greater accessibility. The mobile system will enable care decisions that are more closely coupled with the state of the underlying tissue and related hemodynamics. It will also allow clinicians and patients to more effectively monitor the benefits of care decisions. The development of the novel and cost-effective optical system to facilitate the imaging of clinically and physiologically meaningful information will fill a void in the medical imaging industry for a point of care solution capable of providing quantitative visualization of physiological processes critical to wound care. The development of the mobile imaging technology will enhance scientific and technological understanding in the areas of optical-tissue image mapping, optoelectronic illumination systems, image processing, clinical applicability and real-time imaging scenarios.