High Frequency Miniature PiezoPump For Ventricular Assist

高频微型PiezoPump用于脑室辅助项目摘要先天性心脏病每年影响数以千计的婴儿。这种疾病最具破坏性的亚类之一是单脑室异常，即婴儿出生时只有一个功能性脑室，而不是两个。尽管研究人员使用了传统的电磁驱动的脑室辅助设备来帮助患者，但这些技术对儿童来说过于笨重，而且无法在不损失功率密度的情况下实现小型化。因此，这一提议的前提是，在液压泵中使用压电材料为传统的电磁VAD提供了一种替代方案。提出的研究计划的新颖性是开发了一种新型的小型高频压电心脏辅助装置，可以作为电源帮助单心室循环的儿童。这一建议的智力价值在于对高频工作的压电材料和小型泵部件之间的关系有了基本的了解。这里的挑战是有效地将能量从压电体转移到模拟的人体循环中，而不需要直接接触血液。这项拟议研究的更广泛影响是工程师和医生之间的跨学科合作，开发专门为儿童和患者量身定做的设备。这项研究还为高中和大学中代表性不足的学生提供了一个进行研究的机会，并与加州大学洛杉矶分校的教职员工和研究生发展导师式的关系。

High Frequency Miniature PiezoPump for Ventricular AssistProject SummaryCongenital heart disease affects thousands of infants every year. One the most devastating subclasses of this disease are single ventricle abnormalities, in which infants are born with one functional ventricle instead two. Although researchers have used traditional electromagnetic driven ventricular assist devices to aide patients, these technologies are too bulky for children and are limited by their inability to be miniaturized without loss in power density. Thus, the premise of this proposal is that the use of piezoelectric materials in a hydraulic pump offers an alternative to traditional electromagnetic VADs. The novelty of the proposed research plan is the development of a novel small scale high frequency piezoelectric cardiac assist device that can be used as a power source to help children with single ventricle circulations. The intellectual merit of this proposal is the development of a fundamental understanding of the relationship between piezoelectric materials operated at high frequency and small-scale pump components. The challenge here is to effectively transfer energy from the piezoelectric to a simulated human circulation without direct blood contact. The broader impact of this proposed research is the interdisciplinary collaboration between engineers and doctors to develop devices specifically tailored for children and patients. This research also gives underrepresented students in high school and universities an opportunity to conduct research and develop mentor style relationships with faculty and graduate students at UCLA.