Gordon Research Conference:2011 Enzymes, Coenzymes and Metabolic Pathways July 10-15, 2011 Waterville, New Hampshire

智力价值：关于酶、辅酶和代谢途径的戈登研究会议将于2011年7月10日至15日在新罕布什尔州沃特维尔的沃特维尔谷度假村举行。也许没有哪个科学领域比酶的研究更需要如此广泛的实验方法、理论框架和创造性的问题解决方案。“酶是如何获得其巨大的速率加速和特异性的？”这个简单而基本的问题很简单，但经过100多年的研究，仍然是一个谜。尽管基因组学、蛋白质组学和代谢组学方法使许多科学领域发生了革命性的变化，但对酶的机制和功能的理解仍然需要精心设计的综合实验，涵盖物理、化学和生物学的范围。了解酶的实际重要性是巨大的，因为它们作为药物靶点和工业催化剂的价值。此外，理解和开发生命过程需要在其代谢途径的背景下理解个体反应。正是在这个层次上，生命才真正超越了化学的总和。本次会议的会议和演讲者将在单酶和整个代谢途径的背景下探讨酶学的基础和应用方面。更广泛的影响：戈登酶、辅酶和代谢途径研究会议是酶学广泛领域最具影响力的会议之一，已经蓬勃发展了60多年。今年的会议由一位女性酶学家担任联合主席，很大一部分演讲者和讨论领袖都是从代表性不足的群体中选出的。此外，本周的八场简短演讲将由来自代表性不足的群体的发言人参加。会议的不紧不慢、开放的形式为研究生和博士后提供了交流机会和智力发展。在许多重要的方面，每年这个独特的聚会为这一研究领域的发展和培养新研究者的发展提供了种子。

Intellectual Merit:The Gordon Research Conference on Enzymes, Co-enzymes, and Metabolic Pathways will be held July 10-15, 2011 at the Waterville Valley Resort in Waterville, New Hampshire. There may be no other field of science that requires such a wide range of experimental approaches, theoretical frameworks and creative problem solving than the study of enzymes. The simple and fundamental question of "How do enzymes obtain their tremendous rate accelerations and specificities?" is simple to ask, but after over 100 years of study, is still enigmatic. Despite many areas of science being revolutionized by genomics, proteomics and metabolomic approaches, the understanding of enzyme mechanism and function still requires carefully designed integrated experiments that cover the spectrum of physics, chemistry, and biology. The practical importance of understanding enzymes is enormous because of their value as drug targets and industrial catalysts. Moreover, understanding and exploiting the processes of life requires that individual reactions be understood in the contexts of their metabolic pathways. It is at this level that life becomes genuinely more than the sum of the chemistry. The sessions and speakers in this conference will explore both fundamental and applied aspects of enzymology in the context of single enzymes and entire metabolic pathways.Broader Impacts:The Gordon Research Conference on Enzymes, Coenzymes, and Metabolic Pathways is one of the most influential meetings in the broad area of enzymology and has thrived for more than 60 years.This year's conference is co-chaired by a female enzymologist, and a significant proportion of the speakers and discussion leaders have been chosen from underrepresented groups. In addition, the eight short talks over the week will be populated with speakers from underrepresented groups. The unrushed, open format of the conference facilitates networking opportunities and intellectual development for graduate students and postdocs. In many important ways this unique gathering each year provides the seeds for growing this field of research and fostering the development of new investigators.