Novel Approaches to Heterocyclic Synthons

本项目的重点是开发有用的新型催化成环反应。在此基础上，提出了利用机理的见解来设计张力杂环合子扩环催化剂的详细方案。从这些催化剂设计和开发研究中获得的信息将用于构建最佳配体框架的手性变体。所得的新型手性催化剂将用于不对称脱对称和动力学分解。同时，将开发新的高效的合成路线来组装这些杂环合成子。这将在一个锅中通过将碳亲核试剂添加到唯一活化的羰基亲电试剂中来完成。通过这个奖项，有机和大分子化学项目支持康奈尔大学化学和化学生物系Jon T. Njardarson教授的研究。Njardarson教授的研究工作围绕着开发新的和有用的方法来构建有价值的杂环框架。这些新合成方法的成功推进将为广泛的重要杂环产品提供途径，这将使学术界和制药行业的研究人员受益。

This project is focused on developing useful new catalytic ring forming reactions. A detailed plan is put forth to utilize mechanistic insights to design new catalysts for the ring expansion of strained heterocyclic synthons. The information gained from these catalyst design and development studies will be used to build chiral variants of the optimal ligand frameworks. The resulting new chiral catalysts will be used for asymmetric desymmetrizations and kinetic resolutions. Concurrently, new and efficient synthetic routes for assembling these heterocyclic synthons will be developed. This will be accomplished in one pot by adding carbon nucleophiles to uniquely activated carbonyl electrophiles. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jon T. Njardarson of the Department of Chemistry and Chemical Biology at Cornell University. Professor Njardarson's research efforts revolve around the development of new and useful methods for building valuable heterocyclic frameworks. Successful advancement of these new synthetic methods will provide access to a wide range of important heterocyclic products, which will benefit researchers both in academia and the pharmaceutical industry.