HETEROCYCLIC APPROACHES TO THE CYCLOPEPTIDE ALKALOIDS

环肽生物碱的杂环方法

• 批准号: 3275379
• 负责人: BRUCE H. LIPSHUTZ
• 金额: $ 10.02万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-08-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3275379
• 关键词: alkaloids; dipeptides; drug design /synthesis /production; heterocyclic compounds; ionophores

The proposed research deals with the incorporation of highly functionalized heterocycles into a cyclophane network which, via one or more mild and efficient chemical events, is unmasked to afford the skeleton characteristic of the cyclo-peptide alkaloids. Each is discussed, therefore, as potential intermediates which are to function as latent diamide/dipeptide equivalents in these schemes. Preliminary work has demonstrated the viability of such an approach in two acyclic systems. The natural products show considerable promise as ionophoric agents, in addition to other biological activities.

拟议的研究涉及将高度官能化的 杂环形成环蕃网络，其通过一个或多个温和的和 有效的化学事件，被揭露，以提供骨架 环肽生物碱的特征。 每一个都被讨论过， 因此，作为潜在的中间体， 二酰胺/二肽等价物。 前期工作已 证明了这种方法在两个非循环系统中的可行性。 的 天然产物显示出相当大的希望作为离子载体， 以及其他生物学活动。