GRK 1431: Transcription, Chromatin Structure and DNA Repair in Development and Differentiation

细胞从环境中接收不同的信号。作为对这些信号的反应，细胞调整其基因表达程序，以便对这些刺激提供适当的应答，这导致发育、分化、增殖或细胞死亡的变化。在分子方面，这通常意味着改变遗传物质的包装（表观遗传重编程），从而改变基因表达。

Cells receive diverse signals from their environment. As a reaction towards these signals, cells adapt their gene expression programme in order to provide an adequate answer to these stimuli, which result in changes in development, differentiation, proliferation or in cell death. In molecular terms, this often means that alterations are made to the packaging of the genetic material (epigenetic reprogramming) so that gene expression changes.