SBIR Phase I: Long Lasting Organic Formulation to Effectively Manage Blood Sucking Diptera

这个小企业创新研究（SBIR）第一期项目将开发一种持久的有机配方，以有效地管理和抑制疾病的蚊子媒介。几十年前禁止使用滴滴涕和其他持久性杀蚊幼剂，在病媒管理方面留下了一个重大空白，此后的几代环境友好化学品和制剂尚未有效填补这一空白。其后果对全世界的人口都是切实可见的。我们现在正经历着更多的痛苦，痛苦，以及蚊子传播疾病的死亡，比滴滴涕可用的时候还要多。生物杀幼虫制剂已被证明在控制蚊子幼虫方面是安全有效的，但需要注意的是，它们的田间寿命很短，需要经常重复使用才能维持控制，这反过来又使它们过于昂贵，无法被大多数地区的媒介控制计划所采用。因此，生物杀幼虫制剂很少用于预防。SBIR项目将弥补这一差距，并增加生物杀幼虫剂的寿命和可用性。成功将间接减轻通常与传统杀虫剂有关的土壤和水道污染。如果SBIR项目成功，这项研究的更广泛/商业影响是开发一种生物，长效杀幼虫制剂，这将显著改变全球寄生蚊的管理方式，使其更加有效，减少疾病和痛苦，拯救生命，同时显著减少非目标效应和环境污染。这是一个每年超过20亿美元的全球市场机会。

This Small Business Innovation Research (SBIR) Phase Iproject will develop a long lasting organic formulation to effectively manage andsuppress populations of mosquito vectors of disease. The banning of DDT andother persistent mosquito larvicides several decades ago has created a major gapin vector management that has yet to be effectively filled by generations ofenvironmentally friendly chemicals and formulations that followed. Theconsequences are tangible to the human population worldwide. We are currentlyexperiencing more pain, suffering, and deaths from mosquito transmitteddiseases than when DDT was available. Biological larvicidal formulations havebeen proven safe and effective in controlling mosquito larvae, with the caveatthat they have a very short field life which requires frequent reapplications tosustain control, in turn making them too expensive for adoption by most areawidevector control programs. Because of this, biological larvicidal formulationsare seldom used preventatively. This SBIR project will bridge this gap andincrease the longevity, and usability, of biological larvicides. Success will result indirect mitigation of soil and waterways pollution commonly associated withconventional pesticides for mosquito control.The broader/commercial impacts of this research are, ifthis SBIR project is successful, the development of a biological, long lastinglarvicidal formulation that will significantly change the way parasitic mosquitoesare managed worldwide, making it much more effective, reducing disease andsuffering, and saving lives while significantly reducing non-target effects andenvironmental pollution. This is a worldwide market opportunity of over$2B/year.