Crystallization and cooperativity in dynamic supramolecular polymers (A03)

我们从熔融状态和溶液状态研究了仿生合成大分子的结构形成，旨在了解聚合物分子不同部分之间的折叠和组装原理。在新的资助期内，人工仿生元件将通过在合成聚合物链中重复放置来合成，能够采用特定的构象，从折叠构象（例如α-螺旋，β-折叠）到展开构象动态变化。所提出的合成大分子在结构上位于生物大分子和纯合成分子之间，可以理解部分展开的大分子的基本结构形成和成核过程。

We investigate the structure formation of biomimetic synthetic macromolecules from either the melt state or the solution state, aiming to understand folding and assembly principles between different segments of a polymer molecule. In the new funding period complex, artificial biomimetic elements will be synthesized by repetitive placement within a synthetic polymer chain, able to adopt specific conformations, dynamically changing from folded (e.g. α-helix, β- fold) to unfolded conformations. The proposed synthetic macromolecules are structurally placed between biological macromolecules and purely synthetic molecules, allowing to understand basic structure-formation and nucleation processes of partially unfolded macromolecules.