Real-Time Non-Contact Sensing of Variations in Cardiorespiratory Volume

Lubecke1160326多普勒雷达有可能提供一种方便、安全、非接触的方法来测量与心肺功能相关的体积。这可能会改变医学诊断和预后应用中监测与血压和通风相关的生命体征的方式。目前常规的呼吸监测方法要么不舒服(肺活计、热敏电阻)，要么不准确(阻抗、心电RSA测量)，而且只有在紧急需要的情况下才会短暂实施，如果有的话。目前的脉压和每搏量评估通常是侵入性导管测量，只对一些ICU患者进行常规测量，或者是非连续的抽查，即医疗保健人员进行基于气动袖带的破坏性测量。这些接触方法还可以改变测量量。以前对心肺活动的非接触式雷达测量的成功仅限于心率评估，因为与在现实生活条件下准确定量描述人体躯干移位相关的技术挑战。克服挑战使无创容量评估成为可能的关键在于智能精密监测系统的研究，该系统可以将环境条件引起的测量变化与实际心肺活动引起的测量变化隔离开来。智力价值：我们建议夏威夷大学马诺阿分校S电气工程系和约翰·A·伯恩斯医学院进行为期三年的合作，开展基础研究，探索用于对久坐不动的人体进行连续非接触心肺容量评估的雷达方法。这一发现可能导致生物传感系统对心肺容量的医学上重大变化敏感，同时保持对受试者之间的生物测定差异和受试者位置变化的区分性和健壮性。这项拟议的努力将促进对生理雷达测量和对人体心肺功能的了解。它还将支持它们交叉点的潜在技术突破，包括新的诊断技术。我们团队的特别优势是结合了多普勒雷达(Lubecke，Boric-Lubecke)和非侵入性心脏病专业知识(Seto)。派？S最近在多普勒心肺传感方面的工作已产生了70多篇论文，一本书的章节和一本合同书，14项发明公开，4项专利申请和一项新兴技术奖。在相关工作中，与派？S合作的研究生在IEEE主要会议的四次学生论文比赛中获得了认可和奖项。广泛影响：该项目的成果可以在生命科学、医疗保健、应急响应和安全/军事行动方面产生有益于社会的有价值的工具。这项研究提供了一个鼓舞人心的教育机会，利用夏威夷S对远程医疗工具的独特需求，接触到历史上一直得不到当地教育和产业机会服务的多元化少数民族学生群体。研究成果将通过课程(生物医学和传感器课程)、本科生研究项目和K-12 STEM外联活动培训具有生物传感器问题意识的新一代工程师，从而与教育相结合。我们的成果将通过科学出版物和研讨会、公开讲座和包括STEM日、学校访问和暑期项目在内的K-12推广活动广泛传播。这项研究代表了更广泛的参与，因为它鼓励少数族裔学生参与，并包括来自EPSCoR州代表人数不足的群体(西班牙裔PI和女性Co-PI)的个人。

Lubecke1160326Doppler radar has the potential to provide a convenient, safe, non-contact approach to the measurement of volume associated with cardiopulmonary function. This may transform the way vital signs related to blood pressure and ventilation are monitored in medical diagnostic and prognostic applications. Current conventional methods of monitoring ventilation are either uncomfortable (spirometer, thermistors) or inaccurate (impedance, ECG RSA measurements), and are implemented only briefly in cases of critical need, if at all. Current pulse pressure and stroke volume assessments are typically invasive catheter measurements, done routinely for only some ICU patients, or non-continuous spot-checks where a health care giver administers a disruptive pneumatic-cuff based measurement. These contact methods can also alter the measured quantities. Previous success with non-contact radar measurements of cardiopulmonary activity have been limited to rate assessment, because of technological challenges associated with accurate quantitative characterization of the displacement of the human torso under real-life conditions. The key to transcending challenges to making non-invasive volume assessment possible lies in the study of smart precision monitoring systems that can isolate measurement variations caused by environmental circumstances from those caused by actual cardiopulmonary activity.Intellectual Merit: We propose a three-year collaborative effort between the University of Hawaii at Manoa?s Electrical Engineering Department and John A. Burns School of Medicine, to conduct fundamental research exploring radar methods for continuous non-contact assessment of cardiorespiratory volume for sedentary human subjects. The findings could result in biosensing systems that are sensitive to medically significant changes in cardiopulmonary volume, while remaining discriminative and robust with respect to biometric variations between subjects and changes in subject position. The proposed effort will advance knowledge in both radar measurement of physiology and the understanding of human cardiopulmonary function. It will also support potential technological breakthroughs at their intersection, including new diagnostic techniques. The particular strength of our team is the combination of Doppler radar (Lubecke, Boric-Lubecke), and non-invasive cardiology expertise (Seto). Recent work by the PI?s on Doppler cardiopulmonary sensing has resulted in over 70 papers, a book chapter and a book under contract, 14 invention disclosures, 4 patent applications, and an emerging technology award. In related work, graduate students working with the PI?s have earned recognition and awards in four student paper competitions at major IEEE conferences.Broader Impact: Outcomes of this project can lead to valuable tools beneficial to society in life-science, healthcare, emergency response, and security/military operations. The research poses a motivating educational opportunity that leverages Hawaii?s unique needs for remote healthcare tools, and reaches out to a diverse population of ethnic minority students that have been historically underserved by local educational and industrial opportunities. Research outcomes will be integrated with education through training a new generation of engineers with the awareness of biosensors issues through courses (biomedical and sensors courses), undergraduate research projects, and K-12 STEM outreach activities. Our results will be disseminated broadly through scientific publications and seminars, public lectures, and K-12 outreach, including STEM days, school visits, and summer programs. This research represents Broadening Participation as it encourages participation by minority students, and includes individuals from underrepresented groups (Hispanic PI, and female Co-PI) from an EPSCoR state.