Sensory-affective Interaction and Body Perception in BPD

BPD的特征是分离症状，包括间歇性躯体感觉整合障碍和身体知觉改变。额顶功能障碍，特别是涉及到颞顶交界处(TPJ)，可能代表着与自我与环境之间的处理和相互作用有关的关键机制。我们提出的项目旨在阐明BPD的精神生物学机制，并评估其对BPD的精神病理学的重要性。在研究1中，在分离诱导或中性控制条件下，我们将使用疼痛和愉悦触摸的加工作为工具来理解与分离状态相关的知觉机制。在研究2中，我们将使用神经导航经颅磁刺激(TMS)方案促进或抑制TPJ或对照部位的活动。我们将研究它对与身体知觉相关的感觉整合的影响，以及具有正价或负价的躯体感觉刺激的处理，以及它们与分离的关联。通过揭示分离状态的心理生物学基础和后果，结果可能会增强我们对BPD复杂知觉变化的理解。

BPD is characterized by dissociative symptoms that include intermittent somatosensory integration deficits and alterations in body perception. Frontoparietal dysfunctions, especially involving the temporo parietal junction (TPJ), may represent key mechanisms related to the processing of and interaction between the self and the environment. Our proposed project aims at the elucidation of psychobiological mechanisms of dissociative states and the evaluation of their importance for the psychopathology of BPD. In study 1, after the induction of dissociation or a neutral control condition, we will perform experiments that use of the processing of pain and pleasant touch as a tool to understand the perceptual mechanisms related to dissociative states. In study 2, we will facilitate or inhibit the activity of the TPJ or a control site using a neuronavigated transcranial magnetic stimulation (TMS) protocol. We will examine its effects on sensory integration associated with body perception and the processing of somatosensory stimuli with positive or negative valence, and their association with dissociation. By revealing the psychobiological basis and consequences of dissociative states, the results might enhance our understanding of the complex perceptual alterations in BPD.