Multi-site modulation of the cerebello-cortical motor network in stroke and healthy aging (C04)

基于功能和结构成像的结果，我们能够成功地将非侵入性脑刺激应用于初级和次级运动区域，以增强中风患者和老年健康受试者受损的运动功能。除了初级和次级运动区，小脑与运动网络紧密相连。试验数据表明，刺激小脑可能会改善运动学习。因此，在接下来的资助期内，我们将评估双焦刺激的效果（例如，脑卒中患者和老年健康受试者的运动行为、学习和脑内连接。

Based on results from functional and structural imaging we were able to successfully apply non-invasive brain stimulation to primary and secondary motor areas to enhance impaired motor functions in stroke patients and old healthy subjects. Besides primary and secondary motor areas, the cerebellum is densely interconnected with the motor network. Pilot data suggest that stimulation of the cerebellum may lead to improved motor learning. Thus, in the following funding period we will evaluate the effects of bifocal stimulation (e.g., of primary motor cortex and cerebellum) on motor behavior, learning and interareal connectivity in stroke patients and old healthy subjects.