MRI: Development of Visual and Neural Assessment Equipment

该提案要求资助设计一个具有以下功能的综合便携式神经视觉评估系统：1)具有用户友好的脚本语言的定制软件，为非工程师编写独立和多个同时对左眼和右眼的视觉刺激，2)同时从视觉刺激中进行眼运动和感觉神经电活动量化，以及3)数据分析算法，以确定潜在的生理测量或生物标志物，这些测量或生物标志物在识别神经和视觉缺陷方面具有敏感性和特异性。这一变革性项目将使基础和临床研究科学家能够评估正常和受损人群的神经视觉功能。该系统将整合到pi的本科和研究生课程中。它每年将使大约200名学生能够在不断发展的生物医学工程领域（例如收集和分析生理数据）培训所需的必要技能。每年将有350多名4年级到12年级的学生参观工程和数学。该项目的第一个应用将是评估生物标志物以帮助诊断轻度创伤性脑损伤（mTBI）。

This proposal requests funding to design an integrated, portable neurovisual assessment system with the following capabilities: 1) custom software with user-friendly script language to program independent and multiple, simultaneous visual stimuli to the left and right eye for non-engineers, 2) simultaneous eye movement and sensory neuro-electrical activity quantification from visual stimuli, and 3) data analysis algorithms to determine potential physiological measurements or biomarkers that are sensitive and specific in identifying neurological and visual deficits. This transformative project will enable basic and clinical research scientists to assess neuro-visual functions in normal and impaired populations. This system will be integrated into the PIs' undergraduate and graduate courses. It will enable about 200 students annually to train in imperative skills needed in the growing Biomedical Engineering field (e.g. collect and analyze physiological data). It will be used for tours to introduce over 350 4th to 12th grade students annually to Engineering and Mathematics. The first application of this project will be to evaluate biomarkers to aid in the diagnosis of mild traumatic brain injury (mTBI).