EAGER: Study of Ultra-High Brightness of Fluorescent Silica Nanoparticles for the use in Bio Imaging Applications

1242214索科洛夫这项热切的提案涉及异常高亮度的荧光纳米颗粒。这项研究是一种新的、完全不同的制造荧光纳米颗粒的方法，被认为是高风险的。同时，由于这种粒子对于广泛的光子应用，包括标记、跟踪、标记，特别是在生物成像和传感中的重要性，它是一种高潜在的回报。为了获得更高的信噪比，需要高亮度的标记颗粒，从而提高传感的灵敏度和/或速度、成像的对比度、降低检测极限等。所提出的研究的优点在于研究具有异常强的荧光发射的二氧化硅纳米颗粒；了解这种现象的本质；以及研究这种方法在生物成像应用中的局限性。

1242214SokolovThis EAGER proposal deals with fluorescent nanoparticles of unusually high brightness. Being a substantially new and radically different approach to making fluorescent nanoparticles, this research is considered to be high risk. At the same time, it is a high potential payoff due to the importance of such particles for a broad range of photonic applications involving tagging, tracing, labeling, and particularly in biological imaging and sensing. High brightness of labeling particles is desirable to attain higher signal-to-noise ratio, and consequently, to increase sensitivity and/or speed of sensing, contrast of imaging, to decrease the limit of detection, etc. The merits of the proposed research are in the study of silica nanoparticles, which have unusually strong fluorescent emission; understanding the nature of this phenomenon; and investigating the limits of this approach for bio-imaging applications.