Evolution of Metabolic Innovation: Aerobic Fermentation in Yeasts as an Example

智力优势：进化领域的核心问题之一是理解重复基因对进化的影响。拟议的研究将有助于通过证明基因复制如何促进代谢创新，特别是酵母的有氧发酵来理解这一点。该研究建立在动力学建模框架上，以研究基因复制如何促进新代谢功能的进化。研究的一个方面还将探讨基因复制和新的基因调控机制的进化联系，以及这些机制如何促进细胞代谢创新。更广泛的影响：本研究将产生重要的更广泛的影响。它将培训学生，包括研究生、本科生和高中生。PI参与了包括少数民族学生在内的多项活动，希望鼓励和支持多样化的下一代进化科学家。酵母的好氧发酵在农业和工业中有着广泛的应用。营养和进化之间的联系本身是一个有吸引力的案例研究，可以教育公众关于进化的主题。

Intellectual Merits: One of the central issues in the evolutionary field is to understand the impact of duplicate genes on evolution. The proposed research will contribute to this understanding by demonstrating how gene duplication contributes to metabolic innovation and specifically to aerobic fermentation in yeast. The research builds on a kinetic modeling framework to investigate how gene duplication contributed to the evolution of novel metabolic functions. One aspect of the research will explore also the evolutionary connection of gene duplication and novel gene regulatory mechanisms and how these contribute to cellular metabolic innovation. Broader Impacts: This research will have important broader impacts. It will train students, including graduate, undergraduate and high school students. The PI is involved in multiple activities to include minority students with the hope to encourage and support a diverse next generation of evolutionary scientists. Aerobic fermentation in yeast has broader implication for agricultural and industrial industries. The link between nutrition and evolution itself represents an attractive case study for the edcuation of the public on the subject of evolution.