Cross Talk between Metabolism and the Nervous System via NMDAR Initiates Interbout Arousal In Hibernating Ground Squirrels

这个项目利用冬眠的北极地松鼠的代谢平静来研究营养需求是如何转化为神经信号的。整个研究计划旨在破译将食物转化为细胞构件的生化途径如何与导致神经信号分子合成的生化途径汇合，特别是神经递质谷氨酸。除了其直接目标外，项目成果将与我们理解气候变化和养分供应对脆弱的北极物种的影响以及我们对许多生物的营养反应和代谢平衡的理解具有重大相关性。这项研究将涉及阿拉斯加原住民学生和为当地社区开展的外联活动。此外，新的和先进的技术和仪器将被引入到EPSCoR州立大学的培训和研究计划中。该项目产生的所有数据将在ftp://www.brains-hibernation.iab.alaska.edu.的数据存储库中公开可用

This project takes advantage of the metabolic quiescence of hibernating arctic ground squirrels to study how nutritional needs are translated into neural signals. The overall research plan is aimed at deciphering how the biochemical pathways that convert food to cellular building blocks converge with those that lead to the synthesis of neural signaling molecules, specifically, the neurotransmitter glutamate. Aside from its direct aims, the project outcomes will have significant relevance to our understanding of the impact that climate change and nutrient availability have on a vulnerable Arctic species and to our understanding of nutritional responses and metabolic balance in many organisms. The research will involve Alaska Native students and outreach activities for the local community. As well, new and advanced technologies and instrumentation will be introduced into training and research programs at this EPSCOR state University. All data generated from this project will be made publicly available in a data repository at ftp://www.brains-hibernation.iab.alaska.edu.