A Workshop on the Molecular Design of Commercial Chemicals for Minimal Unintended Biological Activity

本次研讨会由化学学部支持，旨在确定知识差距并制定行动计划以填补这些差距，以解决化学可持续性的重大挑战之一：设计具有最小意外生物活性的化学产品。因此，研讨会将确定从现有工具、知识、数据和基础设施出发应对这一挑战所需的进展和协同合作。此外，讲习班将有助于确定需要鼓励创新的具体领域，以实现更安全化学品设计的目标。研讨会将探讨跨学科的方法，并阐明一个系统级的观点，设计化学产品与最小的意外生物活性。这需要化学、化学和环境工程、毒理学、公共卫生、环境卫生科学和公共政策方面的代表共同努力。对基础科学的复杂性和多学科性质采取结构化的方法将为社区提供教育效益，使其能够开发独特的课程和推广材料。由讲习班参与者撰写的同行评议的共识出版物将提高人们对科学现状和未来需求的认识，以实现从基本原理设计更安全化学品的目标。

This workshop, supported by the Division of Chemistry, aims to identify knowledge gaps and develop an action plan to fill these gaps in order to address one of the grand challenges in chemical sustainability: design of chemical products with minimal unintended biological activity. As such, the workshop will define the required advances and synergistic collaborations to meet this challenge starting from existing tools, knowledge, data and infrastructure. Furthermore, the workshop will help identify specific areas where incentives for innovation are necessary to address the goals of safer chemical design.The workshop will explore interdisciplinary approaches and articulate a systems-level view of design of chemical products with minimal unintended biological activity. This will require collaborative efforts from representatives in chemistry, chemical and environmental engineering, toxicology, public health, environmental health sciences and public policy. A structured approach to the complex and multidisciplinary nature of the underlying science will provide educational benefits to the community, enabling the development of unique curriculum and outreach materials. A peer-reviewed consensus publication written by workshop participants will raise awareness of the current state of the science and future needs to achieve the goal of designing safer chemicals from first principles.