Collaborative Research in Biophotonics: Implantable sensor for brain blood flow mapping

该项目将开发一个新的生物光子学平台，该平台使用薄膜有机半导体材料，能够以薄而灵活的形式产生和探测光。所提出的架构既克服了先前演示的可植入系统的局限性，也克服了传统上与薄膜系统相关的挑战（环境稳定性和设备交叉耦合）。他们将使用柔性有机发光二极管（oled）和有机光电探测器（opd）建立一系列血流监测仪，以绘制大脑中的氧合和总血红蛋白，随着项目的进展，其尺寸、规模和复杂性将不断增加。他们将使用模拟条件测试和植入设备演示系统的功能和稳定性。该平台采用OLED技术，该技术对显示器产生了重大影响，为生物研究构建了一种变革性光源，能够在几乎任何配置中植入，并可用于长时间成像大面积的反射率和荧光。这种薄而灵活的平台可以为广泛的成像、光遗传学、荧光测量和其他生物光子应用带来新的视角和能力。该奖项由生物技术局的IDBR项目（生物研究仪器开发）和工程局的生物光子学项目共同资助。

1264927/1264948Kymissis/MaThis program will develop a new platform for biophotonics using thin film organic semiconductor materials capable of generating and detecting light in a thin, flexible form factor. The proposed architecture overcomes both the limitations of previously demonstrated implantable systems, as well as the challenges (environmental stability and device cross-coupling) traditionally associated with thin film systems. They will build a series of blood flow monitors using flexible organic light emitting diodes (OLEDs) and organic photodetectors (OPDs) to map both oxygenation and total hemoglobin in the brain, increasing in size, scale, and complexity as the program progresses. They will demonstrate the functionality and stability of the systems using both simulated condition testing and implanted devices. This platform applies OLED technology, which has had a significant impact in displays, to build a transformative light source for biological research that is capable of implantation in nearly any configuration and can be used to image reflectance and fluorescence over large areas for extended periods of time. This thin, flexible platform can bring this new perspective and capability to a broad class of imaging, optogenetic, fluorescence measurement, and other biophotonic applications.This award is co-funded by the IDBR program (Instrument Development for Biological Research) in the BIO Directorate, and Biophotonics program in the Engineering Directorate.