Chiral Polycyclic Aromatic Architectures

在这个由化学系化学合成计划资助的项目中，杜兰大学化学系的小罗伯特·A·帕斯卡教授将探索合成新型构型稳定的手性多环芳香分子。除了螺烯以外，这类结构很少见，通常很难合成，它们的性质在很大程度上还没有被探索。提出了四类新的这类化合物，它们的合成非常短，并且很容易修改以调节形状和性质。它们的结构特征确保了外消旋的高势垒和一般的高热稳定性，并且大多数分子应该是强发光的。这些化合物的拆分对映体具有很高的旋光度、很强的圆二色性和较强的圆偏振发光，在某些情况下可能会受到外界因素(温度、光等)的调制。这类分子具有良好的光物理和手性，使其有望作为有机电子材料，特别是在显示技术或电光调制器中应用。预期的结构可作为手性催化剂或手性主体应用于分离技术或医学诊断。这项研究本身将为各种本科生和研究生科学家提供培训，包括女性和代表性不足的少数族裔，他们稍后将进入科学、工程和医学等富有成效的职业生涯。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Robert A. Pascal, Jr., of the Department of Chemistry at Tulane University will explore the synthesis of new types of configurationally stable, chiral, polycyclic aromatic molecules. With the exception of the helicenes, such structures are quite uncommon and often difficult to synthesize, and their properties are largely unexplored. Four new classes of these compounds are proposed, with syntheses that are very short and easily modified for the tuning of shapes and properties. Their structural features ensure both high barriers to racemization and generally high thermal stability, and most of the molecules should be strongly luminescent. The resolved enantiomers of these compounds are expected to show very high optical rotations, strong circular dichroism, and strong circularly polarized luminescence, which in some cases may be modulated by external factors (temperature, light, etc.).The expected photophysical and chiroptical properties of this class of molecules make them candidates for application as organic electronic materials, particularly in display technologies or as electrooptic modulators. The expected structures may lend themselves to application as chiral catalysts or chiral hosts for separation technologies or medical diagnostics. The research itself will provide training for a variety of undergraduate and graduate scientists including women and underrepresented minorities, who will later enter into productive careers in science, engineering, and medicine.