Planning Grant: I/UCRC for Design and Advanced Manufacturing of Integrated Microfluidics for Ubiquitious Diagnostics

1266193加州大学欧文分校；亚伯拉罕李1266195辛辛那提大学；Ian Papautsky提议的中心将开发低功耗、自动化、独立、批量生产的微型设备，能够进行多步骤生化评估。加州大学欧文分校（UC-I）和辛辛那提大学（UCINN）正在合作建立拟议的中心，UCI是牵头机构。该中心的目标是为环境、农业和人类健康的普遍诊断和评估开发先进的制造技术。该中心的目标将通过三个协调的基础和应用研究重点领域来实现：可制造工艺和材料，样品处理和检测，以及集成和控制系统。该中心将产生(a)可以转移给工业利益相关者用于产品开发的进步，(b)为政府实验室提供进一步具体应用开发的技术，以及(c)教育和培训一支熟练掌握低成本可制造微流控生物芯片创新的专业科学家和工程师队伍。更广泛的影响包括竞争性的招聘机制和吸引优秀学生的跨学科合作研究生研究机会，包括代表性不足的群体的成员。除了传统和会议之外，知识传播还包括一个开源的“微流控函数库”，其中包含根据应用和芯片制造过程组织的微流控电路和可互换组件的设计规范。可扩展的原型制作过程也将传播到学术界和工业界，包括成熟的公司和企业家，其目标是大大减少学习曲线，简化从想法到产品的过程。

1266193 University of California-Irvine (UC-I); Abraham Lee 1266195 University of Cincinnati; Ian Papautsky The proposed center will develop low-power, automated, self-contained, mass-produced micro-devices capable of multi-step biochemical assessments. University of California, Irvine (UC-I) and the University of Cincinnati (UCINN) are collaborating to establish the proposed center, with UCI as the lead institution. The goal of the proposed Center is to develop advanced manufacturing technologies for ubiquitious diagnostics and assessment of the environment, agriculture, and human health. The goals of this proposed Center will be achieved via three coordinated basic and applied research thrust areas: Manufacturable Processes and Materials, Sample Processing and Detection, and Integration and Control Systems. This Center would result in (a) advances that can be transferred to industrial stakeholders for product development, (b) technologies that feed into government laboratories for further application-specific development, and (c) the education and training of a cadre of specialized scientists and engineers skilled in low-cost manufacturable microfluidic biochip innovation. Broader impacts include competitive recruitment mechanisms and attractive cross-disciplinary collaborative graduate research opportunities to engage excellent students, including members of underrepresented groups. In addition to traditional and conferences, knowledge dissemination includes an open-source "microfluidic function library" containing design specifications for microfluidic circuits and interchangeable components organized by application and chip manufacturing processes. Scalable prototyping processes also will be disseminated to academia and industry, including established companies and entrepreneurs, with a goal to dramatically reduce the learning curve and streamline the idea-to-product process.