Novel Approaches to Heterocyclic Synthons

在这个由化学部化学合成项目资助的项目中，亚利桑那大学化学和生物化学系的Jon T. Njardarson教授将开发有用的新杂环反应。提出的新反应分为两类：1)新的催化环扩张反应和2)新的阴离子级联反应。最重要的反应的不对称变化也将被研究。除了提供有用的新方法外，所提出的研究将对手性反离子催化的新兴领域做出贡献，并扩展关于理想阴离子跳基团的形成以及如何最有效地将其用于阴离子级联的知识。杂环化合物是药物中最重要的结构支架之一，同时在许多其他材料应用中也起着关键作用。提出的新的杂环方法将为制药工业和其他领域以及学术界的研究人员提供新的和互补的方法来构建重要的结构。此外，该项目将为本科生和研究生提供良好的培训。特别值得注意的是，与这些项目相关的学生所参与的成果是独特的免费教育/研究工具，如疾病聚焦药物海报，Top200药物海报和免费应用程序/网站Chemistry By Design。这些新的互联网工具提供了学习有机化学及其对社会重要性的途径。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Jon T. Njardarson of the Department of Chemistry and Biochemistry at The University of Arizona will develop useful new heterocyclic reactions. The proposed new reactions fall into two reaction classes: 1) new catalytic ring expansions and 2) new anionic cascades. Asymmetric variations of the most significant reactions will also be studied. In addition to delivering useful new methods, the proposed research will make contributions to the emerging field of chiral counterion catalysis as well as expanding the knowledge of what makes an ideal anionic hopping group and how to most effectively use it for anionic cascades. Heterocyclic compounds are one of the more important structural scaffolds found in pharmaceuticals while also playing key roles in numerous other material applications. The proposed new heterocyclic methods will provide researchers in the pharmaceutical industry and other fields as well as academia with new and complementary approaches for building important structures. In addition, this project will provide excellent training of undergraduate and graduate students. Particularly noteworthy deliverables, which the students associated with these projects are involved in, are unique freely accessible educational/research tools such as Disease Focused Pharmaceutical posters, Top200 Drug posters and the free app/website Chemistry By Design. These new internet tools provide access to learning about organic chemistry and its importance to society.