Microgel catalysts mimicking glycosidases

在这个由化学部的大分子、超分子和纳米化学项目资助的项目中，位于费耶特维尔的阿肯色州大学的Susanne Striegler研究了选择糖酰胺作为糖苷水解反应的假定过渡态类似物，评估了铜（II）络合物作为碱性溶液中糖苷水解的催化剂，并研究了来自反相细乳液的微凝胶催化剂。该研究涵盖合成、光谱评估、分子识别和材料科学，并为本科生和研究生提供培训机会。所提出的催化剂具有突出的科学和工业价值，有望为缩短糖缀合物和具有潜在药理学重要性的生物标志物的合成提供一个新的平台。对社会更广泛的影响包括团队对当地高中和中学的推广工作，以及新的课堂教学风格的发展，以促进学生的保留，提高毕业率，减少成本和准备时间，直到毕业。

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Susanne Striegler of the University of Arkansas at Fayetteville studies selected glyconoamidines as putative transition state analogs of glycoside hydrolysis reactions, evaluates copper(II) complexes as catalysts for glycoside hydrolysis in alkaline solution and investigates microgels catalysts derived from inverse miniemulsions. The research encompasses synthesis, spectroscopic evaluation, molecular recognition and material science and provides training opportunities for undergraduate and graduate students.The proposed catalysts are of outstanding scientific and industrial interest and are expected to provide a novel platform for a shortened synthesis of glycoconjugates and biomarkers of potential pharmacological importance as a long term goal. Further broader impacts on society include outreach efforts of the team to local high and middle schools, and the development of new classroom teaching styles to facilitate student retention, increase graduate rate, and decrease costs and preparation time until graduation.