SusChEM: Dendrimer-like Biopolymer: A New Material Platform to Deliver Active Ingredients

ID：MPS/DMR/BMAT(7623)1310475 PI：姚，袁ORG：普渡大学标题：SusChEM：树枝状生物聚合物：提供活性成分的新材料平台技术：活性成分的提供(AIS)一直是从食品和农业应用到制药创新的关键技术领域。由于开发了控制合成载体结构和功能的方法，合成载体获得了极大的关注。相比之下，丰富和可持续的生物基材料的结构规律性一直很难实现，导致它们作为精心制造的载体稀缺。为了应对这一挑战，PI和他的同事们一直在探索用于人工智能交付的生物基材料。因此，来自植物的树枝状生物聚合物(DLB)已被确定为一种潜在的人工智能保护和传递材料。该项目的目标是探索DLB作为产生功能性生物基材料的平台，重点是它们改善难溶于水的人工免疫物质的溶解性的能力。其具体目的是：(1)制备不同粒径和化学性质的DLB纳米颗粒，并检测其细胞毒性；(2)评价DLB结构对模型AI分子的溶解性和稳定性的影响；(3)评估DLB-AI复合体的体外消化率，检测DLB结构对模型AI分子的Caco-2细胞单层通透性的影响。非技术性：当丰富和可持续的生物基材料与尖端技术相遇时，它们的价值会极大地增长。设想从一望无际的农田中收获数百万磅的生物材料，并对其进行定制工程，以改进药物配方和输送，增强食品安全和营养，并促进农业实践。这就是SusChEM项目将有助于实现的目标。在普渡大学，项目组致力于可持续材料研究，通过以下方式促进卫生系统的关键领域：(1)纳米和生物基材料的基础研究活动，(2)与制药业的伙伴关系，以及(3)跨学科教育活动。在这一项目的支持下，私人投资机构将在可持续健康材料的总主题下创造和传播新的知识和技术。该项目将帮助学生和行业专业人士在他们的学习、研究和技术开发中更好地理解或利用材料科学。

ID: MPS/DMR/BMAT(7623) 1310475 PI: Yao, Yuan ORG: Purdue UniversityTitle: SusChEM: Dendrimer-like Biopolymer: A New Material Platform to Deliver Active IngredientsTechnical: Delivery of active ingredients (AIs) has been a critical technology arena spanning from food and agricultural applications to pharmaceutical innovations. Synthetic carriers have gained enormous attention thanks to the means developed to control their structure and functionalities. In contrast, the structural regularity of abundant and sustainable biobased materials has been difficult to achieve, leading to their scarcity as well-fabricated carriers. To address this challenge, the PI and his co-workers have been consistently exploring biobased materials for AI delivery. As a result, dendrimer-like biopolymer (DLB) from plants has been identified as a potential material for AI protection and delivery. The goal of this project is to explore DLB as a platform for generating functional biobased materials, with a focus on their capability to improve the solubility of poorly water-soluble AIs. The specific aims are to: (1) prepare DLB nanoparticles with various particle sizes and chemical properties and examine their cytotoxicity, (2) evaluate the impact of DLB structure on the solubility and stability of model AI molecules, and (3) assess in vitro digestibility of DLB-AI complexes and examine Caco-2 cell monolayer permeability of model AI molecules as affected by DLB structure. Non-Technical: When abundant and sustainable biobased materials meet with cutting-edge technologies, their values grow enormously. Envision that millions of pounds of biomaterials are harvested from endless crop fields and custom-engineered to improve drug formulation and delivery, enhance food safety and nutrition, and advance agricultural practices. That is what this SusChEM project will help to achieve. At Purdue University, the project team is committed to sustainable materials research that promotes key areas in health systems through: (1) basic research activities in nano and biobased materials, (2) partnership with the pharmaceutical industry, and (3) interdisciplinary educational activities. Supported by this project, the PIs will create and disseminate new knowledge and technologies under the general theme of sustainable materials for health. The project will help students and industry professionals to better understand or utilize materials science in their learning, research, and technology development.