CONFERENCE: 2013 FASEB Conference on Genetic Recombination and Genome Rearrangements to be held July 21-26, 2013 in Steamboat Springs, CO

学术价值：美国实验生物学学会联合会(FASE B)关于基因重组和基因组重排的会议将于2013年7月21-26日在科罗拉多州的斯普林斯举行。基因重组在塑造基因组结构和维持所有生物体的基因组完整性方面起着关键作用。DNA损伤可由环境因素或内源性过程造成，最明显的是染色体复制过程中的错误和机械性故障。基因重组，包括同源和非同源，修复了这种损伤。这些修复事件有可能造成基因变化，而不准确的修复导致的染色体重排往往与向癌症的过渡有关。对于有性生殖，同源重组确保了减数分裂过程中适当的染色体分离，并产生了遗传多样性。程序性染色体重排在免疫系统的细胞以及致病微生物中产生多样性。虽然在理解基因重组的机制和生物学后果方面已经取得了相当大的进展，但关于这一基本生物过程的基本机制和调控仍有许多需要了解的地方，会议致力于朝着这一目标取得进展。课程包括生物化学和重组机制、真核生物和原核生物中复制、修复和重组之间的联系、减数分裂、基因组重排和进化，以及基因组完整性的维持。更广泛的影响：任何科学领域的进步都是由研究人员之间的交流促进的，这是会议的一个重要目标。它将召集大约200名研究人员，他们在一系列生物系统中用不同的实验方法研究重组的不同方面。所有与会者都发表了平台或海报演示，涵盖了新的和未发表的作品，所有参与者都有充分的机会进行讨论。摘要书将提供摘要和与会者联系信息，以促进超出会议时间框架的互动。进步还需要吸收某一领域的新研究人员。特别努力吸纳年轻调查人员和代表人数不足的群体成员，包括妇女；对许多人来说，这将是他们第一次有机会发言。为了进一步促进这一目标，六分之一的讲台时段被分配给从摘要中挑选出来的演讲，预计将面向年轻的调查人员。“与专家见面”会议致力于促进演讲者与其他与会者之间的互动，特别是研究生和博士后。此外，还将利用旅行奖学金鼓励青年调查员、受训人员和任职人数不足的团体成员参加。

Intellectual Merit: The Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements will be held July 21-26, 2013 in Steamboat Springs, Colorado. Genetic recombination plays a key role in molding genome structure and maintaining genome integrity in all organisms. DNA damage can be produced by environmental agents or by endogenous processes, most notably by errors and mechanistic failure during chromosome replication. Genetic recombination, both homologous and non-homologous, repairs this damage. These repair events have the potential to create genetic change, and chromosome rearrangements caused by inaccurate repair are often associated with the transition to cancer. For sexual reproduction, homologous recombination ensures proper chromosome disjunction during meiosis and generates genetic diversity. Programmed chromosomal rearrangements generate diversity in cells of the immune system, as well as in disease-causing microorganisms. While considerable progress has been made in understanding the mechanisms and biological consequences of genetic recombination, much remains to be learned regarding the underlying mechanisms and regulation of this fundamental biological process, and the conference is devoted to progress towards this goal. Topics to be covered include biochemistry and mechanisms of recombination, connections between replication, repair and recombination in eukaryotes and prokaryotes, meiosis, genome rearrangements and evolution, and maintenance of genome integrity. Broader Impacts: Progress in any scientific field is fostered by communication between researchers, and this is an important aim of the conference. It will assemble about 200 investigators who study diverse aspects of recombination, in a range of biological systems and with different experimental approaches. All attendees give platform or poster presentations covering new and unpublished work, and there is ample opportunity for discussion from all participants. An abstract book will provide abstracts and participant contact information, to facilitate interaction beyond the time frame of the meeting. Progress also requires the incorporation of researchers who are new to a field. Special efforts are made to include young investigators and members of underrepresented groups, including women; for many, this will be their first opportunity to present. To further promote this goal, one in six platform slots are allocated to talks selected from abstracts, and are expected to be directed to young investigators. A "Meet the Experts" session is dedicated to fostering interaction between speakers and other attendees, especially graduate students and postdocs. In addition, travel scholarships will be used to encourage participation by young investigators, trainees and by members of underrepresented groups.