Cell hydration- and osmolyte-dependence of liver damage and regeneration (A05)

在前期工作的基础上，该项目使用新型动物模型研究了铵和谷氨酰胺代谢、肝细胞异质性以及β 1-整联蛋白在细胞体积变化、胰岛素和牛磺熊去氧胆酸盐的传感/信号传导中的作用。重点研究了氨转运蛋白RhBG、牛磺酸转运蛋白TauT和GAT 2、肝转氨酶（Gls 2）和细胞间谷氨酰胺循环对氨稳态的作用。进一步的研究主题集中在静脉周围谷氨酰胺合成酶阳性的静脉周围清道夫细胞的异质性和突变的谷氨酰胺合成酶的“蛋白质修复”。

Based on the preliminary work the project investigates ammonium and glutamine metabolism, hepatocyte heterogeneities and the role of ß1-integrin in the sensing/ signalling of cell volume changes, insulin and tauroursodeoxycholate using novel animal models. In the focus are studies on the role of the ammonium transporter RhBG, the taurine transporters TauT and GAT2, liver glutaminase (Gls2) and intercellular glutamine cycling for ammonia homeostasis. Further research topics focus on heterogeneities of perivenous glutamine synthetase-positive perivenous scavenger cells and "protein repair" of mutated glutamine synthetase.