EAGER: ASYMMETRIC CHLORINATION

凭借这一热切的奖项，化学合成计划资助莱斯大学的K.C.Nicolaou教授尝试开发第一个可行的催化不对称烯烃二氯化反应。尽管显然风险很高，但在这项研究中调查的任何烯烃类的成功都将代表着高回报，可能会对天然产品、医药、工艺和组合化学努力产生影响。Nicolaou团队将探索互补的有机催化和有机金属途径来实现标题转化，手性支架中的金鸡纳生物碱有望实现不对称性，并将探索相对非极化的烯烃和α，β-不饱和羰基种类的极化烯烃。如果成功，催化不对称二氯化转化有望在学术和工业环境中产生广泛的科学影响。考虑到要探索的有机、无机和有机金属化学的多样性，学生们有望从这种广泛的综合培训中受益。国际和平研究所计划将来自传统上代表性不足的群体的妇女和化学家纳入这一研究团队事业。

With this EAGER award, the Chemical Synthesis Program is funding Professor K.C. Nicolaou of Rice University to attempt to develop the first viable catalytic, asymmetric olefin dichlorination. Though clearly of high risk, success across any of the olefin classes to be investigated in this study, would represent high reward, with a likely impact on natural product, medicinal, process and combinatorial chemistry endeavors. The Nicolaou group will explore complementary organocatalytic and organometallic avenues toward the title transformation, with cinchona alkaloids among the chiral scaffolds expected to impart asymmetry, and with both relatively non-polarized alkenes and polarized alkenes of the alpha,beta-unsaturated carbonyl variety to be explored.If successful, a catalytic asymmetric dichlorination tranformation is expected to have broad scientific impact, across both academic and industrial settings. Given the diverse array of organic, inorganic and organometallic chemistries to be explored, students are expected to benefit from this broad synthetic training. The PI plans to work to include women and chemists from traditionally underrepresented groups in this research team undertaking.