EAGER: Fluorescence Studies of Surface Micro-heterogeneity in Thermoacidophile Lipid Membranes

稳定脂质体在药物配方（甚至护肤品）中有许多潜在的用途。能够承受高压灭菌的脂质体特别适合医疗应用。PI建议使用荧光标记来研究高度稳定的双极膜（脂质体），这些荧光标记可以探测不同膜深度或不同侧位的膜特性。具体来说，他假设沿膜法向和膜平面应该存在显著的结构和功能异质性，这对于理解这些超稳定结构的膜结构-功能关系至关重要。从这项研究中获得的结果将加强对古菌膜中脂质-蛋白质相互作用和溶质渗透的理解，并将在技术应用中产生深远的影响，例如用于生物传感器的非常稳定的脂质基质，光收集装置和用于靶向成像和治疗的纳米颗粒。

Abstract#1350841Chong, Parkson L.Stable liposomes have many potential uses in drug formulations (and even skin-care products). Liposomes that can withstand autoclaving are especially desirable for medical applications. The PI proposes to investigate highly stable bipolar membranes (liposomes) with fluorescent tags that probe membrane properties at different membrane depths or at different lateral positions. Specifically, he hypothesizes that there should be significant structural and functional heterogeneities along the membrane normal and in the plane of the membrane, which are of critical importance in understanding membrane structure-function relationship for these ultra-stable architectures.The results obtained from this research should enhance the understanding of lipid-protein interactions and solute permeation in archaeal membranes and will have profound implications in technological applications, such as extraordinarily stable lipid matrix for biosensors, light harvesting devices, and nanoparticles for targeted imaging and therapy.