IRES: Application of Biochemistry and Analytical Chemistry for Real-World Tasks in Ppublic Health and Biomedicine

这一IRES奖项将为韩国西肯塔基大学(WKU)在釜山国立大学和昌原国立大学的本科生提供研究经验。西卡罗来纳大学的学生将与PI或Co-Pi以及各自的韩国合作者一起开展生物化学和分析化学方面的项目。国际和平研究所、西九龙大学的金文秀教授和釜山国立大学的杨海植教授将合作使用序列特异的锌指蛋白(ZFP)和转录激活因子样效应器(TALE)来检测病原体。他们寻求通过使用带有氧化还原循环的电化学检测来提高这项技术的检测灵敏度。预计该项目将开发一种用于病原体检测的护理点诊断方法。来自西九龙大学的Eric Conte教授和来自昌原国立大学的Lee Yong-Ill教授将合作使用磁性氧化锆颗粒来分离手性外消旋药物混合物。手性外消旋混合物的分离在生物医学中是一个挑战，通常只有一个对映体具有生物活性。磁性氧化锆粒子在分离一些重要的外消旋混合物和随后分离具有重要生物学意义的手性分子方面显示出很好的前景。分离和分离具有药物活性的手性物质对于研究药物-S代谢途径非常重要。来自一所以本科为主的机构的西科大研究人员与两所国际公认的博士授予机构(釜山大学和昌原国立大学)的韩国合作者将加强合作，涉及西科大本科生。此外，这种体验的目的是让学生在不同的文化环境中接受教育。他们将获得对本国以外的高等教育的欣赏，并在国际环境中获得研究经验。此外，还将产生更大的文化鉴赏力。WKU的学生在学年期间将在Pi或Co-Pi的实验室工作，并在暑假参观他们所在的韩国大学。来自西昆士兰大学的合格代表不足的学生将优先参加这次海外访问，包括来自附近阿巴拉契亚地区县的学生。这些学生最不可能有机会去异国他乡，而且总体上缺乏接触不同文化的机会。

This IRES award will provide research experiences to undergraduate students from Western Kentucky University (WKU) in South Korea at Pusan National University and Changwon National University. The WKU students will work on projects in biochemistry and analytical chemistry with the PI or Co-PI and respective South Korean collaborators. The PI, Professor Moon-Soo Kim from WKU, and Professor Haesik Yang from Pusan National University will collaborate on the use of sequence-specific Zinc Finger Proteins (ZFPs) and Transcriptional Activator-Like Effectors (TALEs) for the detection of pathogens. They seek improvements in detection sensitivity for this technique by using electrochemical detection with redox cycling. The development of a point-of-care diagnostic for pathogen detection is expected from this project. The Co-Pi, Professor Eric Conte from WKU, and Professor Yong-Ill Lee from Changwon National University will collaborate on the use of Magnetic Zirconia particles for the separation of chiral racemic drug mixtures. The separation of chiral racemic mixtures is a challenge in biomedicine where typically only one enantiomer will have biological activity. Magnetic zirconia particles show promise for separating a number of important racemic mixtures and subsequent isolation of the biologically important chiral molecule. Separating and isolating the pharmaceutically active chiral substance is important for studying a drug?s metabolic route.A strengthened joint collaboration, involving WKU undergraduate students, will result between the WKU investigators from a predominately undergraduate institution and Korean collaborators at two internationally recognized Ph.D. granting institutions (Pusan and Changwon National Universities). In addition, this experience is designed to expose students to education within a different cultural milieu. They will gain an appreciation for higher education in a country other than their own and gain research experience in an international environment. Also, a greater cultural appreciation will result. WKU students will work in the laboratory of the PI or Co-PI during the academic year and visit their host Korean University during the summertime. Qualified underrepresented students from WKU will be given priority for this overseas visit, including students from nearby Appalachian counties. These students will be least likely to have the means to visit a foreign land and in general lack exposure to diverse cultures.