Fabrication of Novel Core-Shell Nanocomposites as Targeted Carriers

本计画旨在设计并制备一组核-壳结构奈米复合物，作为新一代的药物输送载体。这种独特的核-壳功能材料由于纳米颗粒核而具有辐射/磁响应释放行为，并且由于表面修饰的介孔金属有机框架外壳而具有良好的生物相容性、超高的负载能力和突出的靶向特异性。这种杂化材料的开发将克服现有的挑战，如低负载能力，差的释放控制。这些材料的应用可能有助于提高药物治疗的功效。

This project intends to design and fabricate a group of core-shell nanocomposites as new-generation carriers for effective drug delivery applications. The unique core-shell functional materials possess radiation/magnetic-responsive release behaviour due to the nanoparticle core, and good biocompatibility, ultra-high loading capacity and outstanding targeting specificity due to the surface-modified mesoporous metal-organic frameworks shell. Development of such hybrid materials would overcome the existing challenges such as low loading capacity, poor release control. The application of such materials may help to improve the efficacy of pharmaceutical therapies.