RUI: Cyclometalated Platinum Complexes Having Selective Reactivity and Applications in Catalytic, Photophysical, and Bio-Organometallic Systems

在这个由化学系化学结构、动力学和机理B计划资助的项目中，巴德学院化学系的克雷格·M·安德森教授将研究过渡金属环化合物的合成。对这些化合物的研究可能会促进对基本催化反应的理解，并最终在具有能量影响的领域做出贡献，因为环金属化合物在人工光合作用装置的研究中是众所周知的。这项工作的另一个非常重要的方面是，它将涉及从一年级到四年级的所有级别的本科生。它还将允许学生在许多不同的技能和技术方面获得经验，如合成、表征和结果分析。学生将接受良好的培训，以便继续进行科学研究，通过书面出版物和口头报告传播他们的工作，并提出新的测试假设。环金属过渡金属络合物是一类用途非常广泛的化合物，其各种应用包括用作催化剂、传感器、人工光合作用装置和生物有机金属试剂。了解配体结构对环金属配合物的选择性和反应活性的影响是很重要的，因为配位环境决定了反应的官能度和有效性。首先，这些环金属化合物的物理和化学性质将进行调整，以最大限度地发挥其益处，其中包括催化和抗癌药物。第二，研究C-H和C-X键活化的区域化学将在合成化学领域进行。第三，将合成几种多异核物种，并研究它们与蛋白质、dna和rna等生物分子的相互作用。

In this project funded by the Chemical Structure, Dynamics and Mechanisms B Program of the Chemistry Division, Professor Craig M. Anderson of the Chemistry Department at Bard College will investigate the synthesis of transition cyclometalated complexes. The study of these complexes may advance the understanding of fundamental catalytic reactions and eventually contribute in areas with energy implications, as cyclometalated complexes are well known in the study of artificial photosynthetic devices. Another very important aspect of this work is that it will involve undergraduates at all levels from first-year to senior students. It will also allow students to gain experience in many diverse skills and techniques such as synthesis, characterization, and analysis of results. The students will become well trained in order to continue further scientific studies, disseminate their work through written publications and oral presentations, and develop new hypotheses for testing.Cyclometalated transition metal complexes are a very versatile group of compounds whose varied applications include acting as catalysts, sensors, artificial photosynthetic devices, and bio-organometallic agents. The effect that ligand architecture exerts on selectivity and reactivity of cyclometalated complexes is important to understand, as the coordination environment determines both reaction functionality and efficacy. First, the physical and chemical properties of these cyclometalated compounds will be tuned to maximize their benefits, which include catalysis and anti-cancer agents. Second, studying the regiochemistry of C-H and C-X bond activation will be examined in the area of synthetic chemistry. Third, several multi-heteronuclear species will be synthesized and their interaction with biomolecules, such as proteins, DNA, and RNA will be examined