RUI: NEW ASYMMETRIC SYNTHESES VIA SPIROAMINOBORATES

通过这一新的奖项，化学合成计划支持波多黎各大学Humacao分校的Margarita Ortiz教授开展一个项目，研究用于选择性制备各种重要化学物质的新型硼酸盐催化剂的开发。用于这些目的的现有催化剂通常价格昂贵、难以提纯、对空气和湿气高度敏感，并且对环境有害。该项目将设计和制备易于获得、价格低廉、易于操作和环境友好的催化剂。由于这项研究将由本科生进行，这将是培养波多黎各新一代科学家的绝佳途径。本项目将研究用于酮及其衍生物的化学和立体选择性不对称还原的新型手性螺氨酸硼酸酯的制备。这些研究旨在为这些底物的对映选择性催化还原提供基础知识，并为氨基酸和醇的手性合成建立新的方案。

With this new award, the Chemical Synthesis Program supports Professor Margarita Ortiz of University of Puerto Rico at Humacao in a project investigating the development of new borate based catalysts for the selective preparation of a variety of important chemical substances. Existing catalysts used for these purposes are often expensive, difficult to purify, highly sensitive to air and moisture, and harmful to the environment. This project will design and prepare catalysts that are readily and inexpensively available, easy to handle and environmentally friendly. Since the research will be carried out by undergraduates, it will be an excellent way to train a new generation of Puerto Rican scientists.This project will investigate the preparation of new chiral spiroamino borate esters to be used for the chemo- and stereoselective asymmetric reduction of ketones and their derivatives. These studies are designed to provide fundamental knowledge of the enantioselective catalytic reduction of these substrates and to establish new protocols for the chiral synthesis of amino acids and alcohols.