Immunoprophylaxis and molecular epidemiology of anthrax and the fate of Bacillus anthracis in living vectors and the environment of Namibia, South Africa, Kenya, and Uganda

该项目包括(1)调查南非、纳米比亚、肯尼亚和乌干达的炭疽病分子和环境流行病学；(2)研究芽孢杆菌(B)的命运。环境栖息地和生活媒介中的炭疽病；(3)山羊的疫苗研究。该项目将应用现代分子指纹技术来研究在牲畜、野生动物和人类以及环境生境中传播的炭疽杆菌的遗传多样性，以及基因与空间、时间和宿主分布之间的关系。噬菌体在有机体、环境和活载体的命运中的作用将在微观世界和实地研究中进行调查。将进行疫苗保护试验，以进一步开发包括非细胞细菌和类毒素疫苗候选的替代兽用疫苗。将在多国学术网络的框架内，通过人员和技术技能交流，促进纳米比亚、南非、肯尼亚、乌干达的青年研究人员和技术人员以及德国科学家的学术和专业生涯。

The project proposed encompasses (1) investigations of the molecular and environmental epidemiology of anthrax in South Africa, Namibia, Kenya, and Uganda (2) studies on the fate of Bacillus (B.) anthracis in environmental habitats and within living vectors and (3) vaccine studies in goats. The project will apply modern molecular fingerprinting techniques to address the genetic diversity of B. anthracis circulating in livestock, wildlife and humans and in environmental habitats and the relationship between genotype and spatial, temporal and host distribution. The role of bacteriophages in the fate of the organism in the environment and in living vectors will be investigated in microcosm and field studies. Vaccine protection trials will be carried out to further develop an alternative veterinary vaccine comprising acellular bacterial and toxoid vaccine candidates. The academic and professional careers of young researchers and technicians from Namibia, South Africa, Kenya, Uganda and of German scientists will be promoted through exchange of personnel and technological skills within the framework of a multi-national academic network.