Understanding biological membranes in atomic detail

该项目的目的是发展以原子细节表示特定哺乳动物、真菌和细菌膜的能力，并利用这些模型了解膜组成在原子一级膜蛋白结构和动力学中的作用。膜蛋白组装是终极的纳米机器。了解这些亚细胞成分既是一个基本的理论挑战，也是生物化学，结构生物学和医学中广泛的实际重要性。通过详细描述生物膜的复杂性，该项目旨在阐明特定膜组分在确定参与环境中运输和信号转导的蛋白质的作用机制中所发挥的作用。

The aim of the project is to develop the capacity to represent specific mammalian, fungal and bacterial membranes in atomic detail and to use such models to understand the role of membrane composition in the structure and dynamics of membrane proteins at an atomic level. Membrane protein assemblies are the ultimate nanoscale machines. Understanding these sub-cellular components is both a fundamental theoretical challenge and of widespread practical importance in biochemistry, structural biology and medicine. By representing in detail the complexity of biological membranes, the project aims to elucidate the role played by specific membrane components in determining the mechanism of action of proteins involved in transport and signal transduction in context.