MRI - Head Injury Biomechanics Measurement System

PI：Pfister，Bryan J.Proposal：1428925标题：MRI-头部损伤生物力学测量系统意义轻度创伤性脑损伤(TBI)和脑震荡目前是一个主要的公共卫生问题，主导着我们的生活，从青少年活动到职业运动再到日常摔倒。据估计，仅在美国就有160万至380万人发生与运动相关的脑震荡。尽管有许多研究努力从医学上描述和治疗脑震荡，但头部创伤本质上是一个生物力学问题。PI在脑外伤和冲击波脑损伤研究方面拥有丰富的经验。他们认为，通过仔细地进行实验和建模，通过规定正确的几何和材料以及初始/边界条件，可以通过指定生物力学边值问题来定义该问题。头部损伤生物力学测量系统将使PI能够控制和测量限制脑震荡条件的生物力学参数。这一努力将导致制定一个类似于制定车祸头部损伤标准的脑损伤标准(BIC)。这一努力将填补目前外伤性脑震荡脑损伤研究中的重要基础知识空白。技术描述PIS和损伤生物力学、材料和医学中心(CIBM3)的主要目标是在头部外部负荷与空间和时间压力以及导致大脑损伤的应变之间建立联系。这里提出的头部损伤生物力学测量系统是一个使能组件，它将使研究人员能够精确复制损伤事件，准确测量多个离散位置的应力和应变，并帮助开发生物逼真计算机模型，以建立外部载荷和组织水平应力状态之间的关系。这将对国际上的研究人员在他们的模型中复制临床相关的生物力学损伤参数来研究脑震荡损伤的创伤机制具有重要意义。所提出的头部损伤生物力学测量系统将是学术研究界的一个独特的系统。这一独特的研究方法除了使用物理假人模型外，还使用身体，这将增加开发BIC的临床相关性，并有可能成为该领域的标准。

PI: Pfister, Bryan J.Proposal: 1428925Title: MRI - Head Injury Biomechanics Measurement SystemSignificanceMild traumatic brain injuries (TBI) and concussions are currently a major public health concern that dominates our lives from adolescent activities to professional sports to everyday falls. An estimated 1.6 to 3.8 million sports-related concussions occur in US alone. Though there are many research efforts to describe and treat concussion medically, trauma to the head is essentially a biomechanical problem. The PIs have extensive experience with TBI and blast brain trauma research. They believe that the problem can be defined by specifying the biomechanical boundary value problem through prescribing the right geometry and material and initial/boundary conditions through carefully conducted experiments and modeling. The head injury biomechanics measurement system will enable the PIs to control and measure the biomechanical parameters that bound concussive conditions. This effort will lead in developing a Brain Injury Criterion (BIC) similar to the development of the Head Injury Criterion for automotive accidents. This effort will fill the important fundamental knowledge gap in current traumatic concussive brain injury research.Technical DescriptionThe major goal of both PIs and the Center for Injury Biomechanics, Materials and Medicine (CIBM3) is to provide a link between external loading of the head to the spatial and temporal stress and strains that cause injury to the brain. The Head Injury Biomechanical Measurement System proposed here is an enabling component that will allow researchers to precisely replicate the injury event, accurately measure stresses and strains at multiple discrete locations and help develop bio-fidelic computer models to establish the relationship between external loading and tissue level state of stress. This will be important to researchers internationally to replicate clinically relevant biomechanical injury parameters in their models to investigate the traumatic mechanisms of concussive injury.The proposed Head Injury Biomechanical Measurement System will be a unique system in the academic research community. This unique research approach of using cadavers in addition to physical dummy models will add clinical relevance towards developing a BIC and the potential to be a standard in the field.