SBIR Phase II: Low cost shortwave infrared (SWIR) spectral imaging microscope camera based on Compressive Sensing

该项目的更广泛的影响/商业潜力是打开价格敏感的研究，医学成像和监测社区短波红外（SWIR）波段的优势，而无需传统高光谱系统的复杂性或费用。本项目研制的多光谱SWIR成像仪支持医学显微镜和小动物红外荧光成像，用于肿瘤的检测、定位和切除。SWIR荧光团不产生自身荧光背景，同时将组织穿透深度和效率提高10倍或更多。针对我国有关矿山截污库坝吗?S成像平台可以通过开发专门的图像处理和分析方法，为制药制造、食品安全、太阳能电池板和半导体检测、机器视觉和导航等特定应用建立巨大的市场。针对我国有关矿山截污库坝吗?S相机平台体现了革命性的压缩感知采样新理论，该领域在信息处理中的应用呈指数级增长。创新的架构和最先进的软件已经嵌入到相机和用户界面中，可以增强和可能改变实验室和临床模式的动态多荧光成像，体内功能成像，组织活力和病理研究，以及先进的成像模式，如光学相干断层扫描。该小型企业创新研究（SBIR）第二阶段项目将开发一种低成本、多色短波红外（SWIR）相机，可直接安装在显微镜上，用于支持科学、工业和生物医学成像领域的微成像应用。该相机的光电、光机械和处理软件架构基于压缩感知，这是一种新的采样技术，可将高分辨率成像的数据收集要求降低到远低于奈奎斯特极限。这种设计不使用昂贵的传感器阵列或复杂的光谱仪。相反，高分辨率的图像是由单探测器测量计算构建的。的吗?单像素相机?InView将architecture作为单色SWIR成像仪商业化。在第一阶段，InView成功地证明了只需对其单色相机设计进行简单的修改就可以产生全彩色成像。第二阶段的目标是仅修改将现有单色相机转换为多色成像仪所需的组件，总体设计目标是保持现有相机的尺寸，重量和成本，以便InView可以为价格敏感的显微镜社区提供低成本的多光谱SWIR成像。

The broader impact/commercial potential of this project is to open price-sensitive research, medical imaging and surveillance communities to the benefits of the shortwave infrared (SWIR) waveband without the complexity or expense of traditional hyperspectral systems. The multispectral SWIR imager developed in this project supports medical microscope and small animal imaging of infrared fluorescence for cancer detection, localization and excision. SWIR fluorophores produce no autofluorescence background while simultaneously enhancing tissue penetration depth and efficiency by factors of 10 or more. InView?s imaging platform can build large markets by the development of specialized image processing and analytical methods for specific applications in pharmaceutical manufacturing, food safety, solar panel and semiconductor inspection, machine vision, and navigation. InView?s camera platform embodies the revolutionary new sampling theory of compressive sensing, a field whose applications in information processing have grown exponentially. The innovative architecture and the state-of-the-art software already embedded in the camera and user interface can enhance and possibly transform lab and clinical modalities in dynamic multi-fluorescence imaging, in vivo functional imaging, tissue viability and pathology studies, and advanced imaging modalities such as optical coherence tomography.This Small Business Innovation Research (SBIR) Phase 2 project will result in an operational low-cost, multi-color shortwave infrared (SWIR) camera that can be directly mounted on microscopes for supporting compelling micro-imaging applications in scientific, industrial and biomedical imaging. The electro-optical, opto-mechanical, and processing software architecture of the camera is based on Compressive Sensing, a new sampling technique that reduces data collection requirements for high resolution imaging to well below Nyquist limits. This design does not use expensive sensor arrays or complicated spectrometers. Instead, high-resolution pictures are computationally constructed from single-detector measurements. The ?single-pixel camera? architecture was commercialized by InView as a monochromatic SWIR imager. In Phase 1, InView successfully demonstrated that only simple modifications to its monochromatic camera design can produce full color imaging. The objective of Phase 2 is to modify only the components that are necessary to transform the existing monochromatic camera into a multi-color imager with the overall design goal of maintaining the existing camera size, weight and cost so that InView can offer low-cost multispectral SWIR imaging to the price sensitive microscopy community.