I-Corps: Development of Novel Technology for Nanoparticle Characterization

PI和他的团队开发了一种名为纳米颗粒跟踪分析多光谱仪器（MANTA）的创新技术，用于在无扰动状态下准确表征纳米颗粒的浓度和大小，这与许多应用和研究领域相关；例如医疗，制药，生化，物理和环境。纳米颗粒标准测试表明，MANTA优于现有的商业技术。MANTA的卓越性能是由于新颖的方法，包括样品照明和纳米颗粒布朗运动的视频记录，以及用于分析视频数据的专有算法和软件。MANTA能够提供有关纳米粒子的信息，以满足当前现有技术无法满足的突出需求，并影响到利用纳米技术的各种工业部门/应用，例如制造诊断、印刷、钻孔和铣削工业，以及化妆品、颜料、油墨、催化剂和纺织品的生产。如上所述，纳米颗粒的浓度和尺寸分布的测量对于许多应用都是至关重要的，因此MANTA技术的潜在客户范围很大，而且多种多样，没有单一的典型客户。MANTA确保在广泛的纳米颗粒尺寸范围内准确确定纳米颗粒的浓度和大小。因此，MANTA的创新解决方案代表了纳米颗粒分析领域的变革性进步和现有技术的主要竞争优势。该小组预计，MANTA将在广泛的健康和环境应用中产生变革性影响，包括疾病和病理状况的诊断、有效和特定疗法的开发、环境风险评估、食品安全以及职业健康和安全风险管理战略。

The PI and his group have developed an innovative technology named Multi-spectral Apparatus for Nanoparticle Tracking Analysis (MANTA) for accurate characterization of nanoparticle concentrations and sizes in an unperturbed state, which is relevant for many applications and research areas; for instance medical, pharmaceutical, biochemical, physical and environmental. Tests with nanoparticle standards demonstrate that MANTA outperforms existing commercial technologies. The superior performance of MANTA is due to novel approaches including sample illumination and video recording of nanoparticle Brownian motion and to proprietary algorithms and software for analysis of video data. MANTA is capable of providing information on nanoparticles meeting outstanding needs not currently met by the existing technologies and that affects a broad variety of industrial sectors/applications which utilize nanotechnology, such as manufacturing diagnostics, the printing, drilling, and milling industries, and the production of cosmetics, pigments, inks, catalysts, and textiles.Because measurements of concentration and size distribution of nanoparticles are essential to many applications as stated above, a range of potential customers for MANTA technology is large and diverse with no single typical customer profile. MANTA ensures that the concentration and size of nanoparticles are accurately determined over a broad range of nanoparticle sizes. The innovative solutions of MANTA thus represent a transformative advancement in the area of nanoparticle analysis and a major competitive advantage over existing technologies. The team expects that MANTA will have transformative effects in a broad range of health and environmental applications, including the diagnosis of disease and pathological conditions, development of efficient and specific therapies, environmental risk assessment, food safety, and occupational health and safety risk management strategies.