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WORKSHOP: Design, Engineering & Selection of Novel Proteins to be held in Arlington, VA; May 12-13, 2014.

WORKSHOP: Design, Engineering & Selection of Novel Proteins to be held in Arlington, VA; May 12-13, 2014.
研讨会:设计、工程
批准号:
1439222
负责人:
Michael Hecht
金额:
$4.96万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-04-01 至 2015-03-31

项目摘要

项目成果

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中文摘要
翻译
大约20位顶尖科学家将参加本次研讨会,讨论有关设计新型蛋白质和酶的“领域现状”。这些科学家代表了广泛的专业知识:一些专门研究新型蛋白质的计算设计,而另一些则专注于选择和优化的进化和组合方法。研讨会的目的将有三个:(i)描述不同学科的贡献如何使我们在设计可折叠和功能的新型蛋白质的能力方面取得巨大进展;讨论这一领域未来发展的潜力,并说明各学科之间的相互促进如何能促进这一进展;(iii)明确讨论可能阻碍这一进展的挑战和/或障碍,并提出使研究人员能够在未来十年克服这些挑战的方法。研讨会将着重于蛋白质设计、工程和选择的基础科学和实际应用。
英文摘要
Approximately 20 leading scientists will attend this workshop to discuss the "state of the field" with respect to designing novel proteins and enzymes. These scientists represent a broad range of expertise: Some specialize in computational design of novel proteins, while others focus on evolutionary and combinatorial methods for selection and optimization. The purpose of the workshop will be threefold: (i) To describe how contributions from different disciplines have enabled enormous recent advances in our ability to devise novel proteins that fold and function; (ii) To discuss the potential for future developments in this field, and describe how cross-fertilization between disciplines can enhance this progress; and (iii) To explicitly discuss challenges and/or roadblocks that might impede this progress, and to propose approaches that will enable researchers to overcome these challenges in the coming decade. The workshop will focus on both basic science and real-world applications of protein design, engineering, and selection.
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