Conference: FASEB Mechanisms of mRNA decay; Big Sky, Montana; July 6 - July 11, 2014

在基因表达过程中，信息从基因组DNA传递到信使RNA (mRNA)，为控制负责特定生物过程的基因提供了重要途径。了解这些过程是如何正常工作的，使我们能够理解当生物体面临环境变化或进化时，它们是如何变化的。近年来，人们发现mRNA降解也是调控基因表达的重要手段。因此，全面了解mRNA降解机制及其调控具有重要意义。最近，干扰RNA在实验中降解特定mRNA的惊人应用超出了任何预期，扩展了理解mRNA衰变机制的应用。2014年7月6日至11日，美国实验生物学协会联合会（FASEB）在蒙大拿州Big Sky召开了mRNA衰变机制会议，汇集了动物、真菌、植物、病毒、细菌和古细菌系统mRNA衰变方面的顶尖专家。这次为期5天的会议的主要好处之一是，它汇集了使用各种方法和生物体研究mRNA降解的专家，提供了交叉受精的机会，并使真核生物和原核生物mRNA降解之间的许多相似之处变得明显。会议的规模和计划组织都支持RNA降解领域的初级研究人员。只有100-150名与会者被安置在同一地点，并且只有在上午和晚上有演讲和海报，预计将有足够的时间和机会在初级和高级与会者之间进行非正式的互动。一些口头报告将从提交的摘要中选出，让初级研究人员有机会展示他们的工作，供社区批判性地观察。此外，海报会议将允许其他人展示他们的作品，以激发对话和反馈。会议期间还将举行专家见面会，并有机会与专家进行更非正式的互动。所有这些方面都被认为是本领域初级调查人员专业发展的积极增强。所要求的经费将用于偿还7位发言者大约一半的费用，其中一些发言者是从提交的摘要中选出的。这项支持的优先对象将是学生、博士后、职业生涯早期的独立研究者，以及美国科学界中代表性不足的群体的成员。

The transfer of information from the genomic DNA to messenger RNA (mRNA) during the process of gene expression provides an important way to control the genes responsible for specific biological processes. Understanding how these processes work normally allows us a means to comprehend how they can change when organisms face alterations in their environment or evolve. Recently, it is clear that mRNA degradation is also an important means for regulating gene expression. Thus, gaining a complete understanding of mRNA degradation mechanisms and its regulation are of critical interest. More recently, the spectacular use of interfering RNA to experimentally degrade specific mRNAs has expanded the applications of understanding mRNA decay mechanisms beyond any expectations. The Federation American Societies for Experimental Biology (FASEB) meeting on mechanisms of mRNA decay from July 6th to 11th 2014 in Big Sky, Montana brings together the leading experts in mRNA decay in animal, fungal, plant, viral, bacterial, and archaeal systems. One of the chief benefits of this 5-day meeting is that it brings together experts who study mRNA degradation using various approaches and organisms, providing the opportunity for cross-fertilization and allowing many parallels between mRNA degradation in pro- and eukaryotes to become evident. Both the size and planned organization of the meeting support junior investigators in the field of RNA degradation. With only 100-150 attendees all being housed in the same venue, and with talks and posters only in the morning and evening, there is expected to be ample time and opportunity for informal interactions between junior and senior attendees. Some of the oral presenters will be selected from submitted abstracts to give junior investigators the opportunity to present their work for critical viewing by the community. In addition, poster sessions will allow others to display their work to stimulate conversations and feedback. There will also be meet-the-expert sessions and opportunities to interact with them more informally during the meeting. All of these aspects are viewed as positive enhancements of the professional development of junior investigators in this field.The requested funds will be used to reimburse seven speakers for about half their costs some selected from submitted abstracts. Priority for this support will be students, post-docs, early-career independent investigators, and members of underrepresented groups who are members of the US scientific community.