EAGER: Cooperative Spectroscopy for Real-time In Vivo Nano-biosensing: Towards Health-centric Smartphones

提案：1445934PI: Jornet， joseph机构：纽约州立大学布法罗分校渴望：实时体内纳米生物传感合作光谱：朝着以健康为中心的智能手机发展意义：该项目有望为生物传感应用的体内纳米传感器网络的发展铺平道路，直接应用于下一代以健康为中心的智能手机和可穿戴设备。这项技术有可能从根本上改变目前的疾病诊断和治疗技术。通过利用协调的纳米设备的分布式网络，提高基于单个纳米生物传感器的现有诊断技术的准确性，这一想法具有变革性。该项目利用一种新的跨学科方法，利用和结合纳米生物传感、无线通信和网络以及分布式数据收集和信号处理技术，为先进健康监测和药物输送系统的更广泛和雄心勃勃的愿景做出了贡献。智力描述：拟议研究的目的是证明协作光谱用于实时体内纳米生物传感应用的可行性。最终目标是用协调的纳米设备网络取代经典光谱学中使用的外部独立激发和测量系统，能够同时激发和测量纳米生物功能粒子的响应。这种方法有几个好处。首先，与传统的光谱学系统相比，该系统的尺寸更小，功耗要求更低，因此可以将该平台集成到下一代以健康为中心的智能手机以及新型可穿戴设备中。其次，将纳米器件放置在与实体密切接触的地方，通过指纹触摸扫描仪或最终进入人体进行测量，从而实现低功耗、低噪声信号的传输和检测。第三，在相互协作的不同纳米设备上收集接收到的信号，可以使用先进的信号处理来进行分布式数据收集，从而实现更准确的传感。

Proposal: 1445934PI: Jornet, JosepInstitution: SUNY at Buffalo EAGER: Cooperative Spectroscopy for Real-time In Vivo Nano-biosensing: Towards Health-centric SmartphonesSignificance:The project is expected to pave the way for the development of in vivo nanosensors networks for biosensing applications with direct application to the next generation of health-centric smartphones and wearable devices. This technology has the potential to radically change current disease diagnosis and treatment techniques. The idea of improving the accuracy of existing diagnostic techniques based on individual nano-biosensors by utilizing a distributed network of coordinated nano-devices, is transformative. This project contributes to a much wider and ambitious vision of advanced health-monitoring and drug delivery systems, using a novel interdisciplinary approach to leverage and combine the state-of-the-art in nano-biosensing, wireless communication and networks, as well as distributed data collection and signal processing.Intellectual Description:The objective of the proposed research is to prove the feasibility of cooperative spectroscopy for real-time in vivo nano-biosensing applications. The ultimate goal is to replace the external independent excitation and measurement system used in classical spectroscopy by a network of coordinated nano-devices, able to both excite and measure the response of nano-biofunctional particles. The benefits of this approach are several. First, the much smaller size and lower power requirements than classical spectroscopy systems will allow the integration of the proposed platform in the next generation of health-centric smartphones as well as new types of wearable devices. Second, the placement of the nanodevices in close contact with the entity to measure on a fingerprint touch scanner or eventually inside the human body, allows for the transmission and detection of low-power, low-noise signals. Third, the collection of the received signal at different nano-devices that collaborate with each other, allows for much more accurate sensing using advanced signal processing for distributed data collection.