Cell recruitment in retinal angiogenesis

增殖性糖尿病视网膜病变最严重的病理是视网膜新生血管的形成。该提案解决了内皮前体细胞和巨噬细胞在视网膜新生血管形成部位的募集作用。我们将评估多能骨髓前体细胞对视网膜血管生成的贡献，并确定招募到视网膜血管壁中的特定干细胞群。在这方面，内皮前体细胞以及髓系细胞将被研究。最后，将评估生长因子和粘附分子在干细胞募集中的作用。

The most severe pathology of proliferative diabetic retinopathy is the formation of retinal neovascularization. This proposal addresses the role of the recruitment of endothelial precursors and macrophages to sites of retinal neovascularization. We will assess the contribution of pluripotent bone marrow precursor cells to retinal angiogenesis and identify the specific stem cell population recruited into the vessel walls of the retina. In this, endothelial precursor cells will be investigated as well as myeloid lineage cells. Finally, the role of growth factors and adhesion molecues in stem cell recruitment will be assessed.