Alkaloid Synthesis Using Aminal Radicals

在这个由化学部化学合成项目资助的项目中，俄勒冈州立大学的Christopher M. Beaudry教授正在开发有效的方法来构建含有氮的复杂结构的分子。由于绝大多数生物活性分子都是含氮的，这项研究将为生物活性分子的鉴定创造新的机会。人们正在测试合成分子作为药物先导化合物、生物探针和细胞蛋白选择性抑制剂的能力。为这项工作做出贡献的研究人员代表了一个多元化的、多种族、多文化、多性别的科学家群体。博德里教授主持每周和每月的正式研究会议，在那里科学家们接受实验和传播工作的培训。此外，多元化的Beaudry小组积极参与社区外展和终身学习，包括俄勒冈科学与工业博物馆，“科学酒吧”，当地组织的科学讨论，以及太平洋西北大学本科生研究研讨会的组织。从技术上讲，该项目侧重于研究和开发以碳为中心的带有两个氮原子的自由基的新化学反应。这些动物自由基被用来在含有杂原子的分子中产生新的碳-碳键，比如药物和天然产物。使用这些自由基可以有效地合成目标分子，同时避免氮的酸碱化学反应，因此代表了化学合成的新策略。

In this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Christopher M. Beaudry of Oregon State University is developing efficient methods for the construction of molecules with complex architectures that contain nitrogen. Since the vast majority of biologically active molecules are nitrogenous, this research will create new opportunities for the identification of biologically active molecules. Synthetic molecules are being tested for their ability to serve as pharmaceutical lead compounds, biological probes, and selective inhibitors of cellular proteins. Researchers contributing to this work represent a diverse multiracial, multicultural, multi-gender group of scientists. Professor Beaudry supervises formal weekly and monthly research meetings where scientists are trained for experimentation and dissemination of the work. Moreover, the diverse Beaudry group actively participates in community outreach and lifelong learning with the Oregon Museum of Science and Industry, "Science Pub," a locally-organized discussion of science, and organization of the Pacific Northwest Undergraduate Research Symposium.More technically, the project focuses on study and development of new chemical reactions of carbon-centered radicals that bear two nitrogen atoms. Such aminal radicals are used to create new carbon-carbon bonds in molecules containing heteroatoms, such as pharmaceuticals and natural products. The use of these radicals allows efficient syntheses of target molecules while avoiding acid-base chemistry of nitrogen, and as such represents a new strategy for chemical synthesis.