SusChem: Innovation Inspired by Amides: Oxidative Ni-catalysis, Cascade Acylations, and Green Peptide Synthesis

化学合成和催化项目是由加州大学欧文分校的Vy Maria Dong教授共同资助的一个项目，旨在确定对环境无害的高效合成化学方法。董教授的研究团队专注于研究廉价且富含土壤的金属作为催化剂成分，使有机分子中形成共同键。该项目提供了通过最小化成本和浪费来制造分子的实用方法。董教授创立的外展计划侧重于会议/研讨会，以支持和促进妇女在有机合成领域的发展。这次会议为南加州的研究生提供了一个网络、合作和交流思想的途径。董教授的研究项目影响了广泛的分子合成，这些分子含有常见的酯和酰胺键。贱金属催化剂的使用有助于满足国家对更高效和可持续化学的需求。对氧化镍催化的追求是一种未开发的反应性模式，可以将醛转化为酯、酰胺和酮。该平台为对映选择性还原和区域选择性酰化提供了独特的途径。所描述的立体选择性酰化有可能影响大量具有手性酯和乙酰氨基酯基序的天然产物的合成路线。研究这一催化过程的机理对相关协同催化方法的影响。最终的目标是追求一种对环境无害的肽合成，作为一种新的方法来解决合成中的一个中心问题，并具有广泛的应用。

The Chemical Synthesis and the Catalysis Programs are co-funding a project by Professor Vy Maria Dong from the University of California at Irvine that aims to identify environmentally benign and efficient methods for synthetic chemistry. Professor Dong's research team is focused on the study of inexpensive and earth abundant metals as constituents in catalysts that allow the formation of common linkages in organic molecules. The project provides practical methods for making molecules by minimizing both costs and waste. An outreach program created by Professor Dong focuses on a conference/workshop to support and promote women in the field of organic synthesis. This meeting provides an avenue for graduate students in Southern California to network, collaborate, and exchange ideas.Professor Dong's research project impacts the synthesis of a wide-range of molecules that contain the commonly occurring ester and amide linkage. The use of base-metal catalysts contributes to the nations need for more efficient and sustainable chemistry. The pursuit of oxidative Ni-catalysis is an unexplored mode of reactivity that enables the conversion of aldehydes into esters, amides, and ketones. This platform provides a unique avenue for enantioselective reductions and regioselective acylations. The stereoselective acylations described have the potential to impact synthetic routes to a vast number of natural products that bear chiral ester and acetamido ester motifs. Studies on the mechanism of this catalytic process impact related cooperative catalytic methodology. The final aim pursues an environmentally benign peptide synthesis as a new approach to a central problem in synthesis with widespread applications.