Sustainable Technologies for Building Molecules: Ethers, Phosphines, and Amino Acids

构建分子的可持续技术：醚、膦和氨基酸

• 批准号: 2247923
• 负责人: Vy Dong
• 金额: $ 57.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2247923&HistoricalAwards=false
• 关键词: Sustainable; Technologies; Building; Molecules; Ethers

With the support of the Chemical Catalysis Program in the Division of Chemistry, Professor Vy Dong of the University of California, Irvine is studying the development of new catalytic reactions to expedite the synthesis of organic molecules with improved efficiency and reduced waste. Earth-abundant nickel catalysts will be investigated for the construction of C-O bonds and unnatural amino acids with precise control of three-dimensional molecular shape. The introduction of selenium into small molecules and the construction of new asymmetric phosphine ligands will also be explored using photocatalysis and copper catalysis. This project sets out to advance understanding of how to build challenging chemical bonds, while also reducing reliance on precious metals. Precisely controlling the shape of molecules is critical for optimization and fine-tuning the performance of medicines and materials; therefore, this proposal is creating tools for molecular construction to empower scientists in other fields to design future therapies and materials technologies. These activities are further expected to provide training for a diverse group of graduate, undergraduate, and high school student researchers. Professor Dong is also leading initiatives to engage students and the public in chemistry discussions via social media and increasing the visibility of role models and networking opportunities for women in chemistry.The development of new catalysts that enable sustainable methods for the enantioselective synthesis of organic molecules is essential to achieve continued advances in the preparation of medicines, materials, and biological probes. This program features catalytic strategies to address modern challenges in synthesis. Under this award, Professor Dong and her research team will pursue the following goals: (1) activating chalcogens for hydrofunctionalization, (2) designing and constructing phosphines and (3) forging novel routes to amino acids and cyclic peptides. These three primary objectives feature transition metal catalysts, including those derived from earth abundant first row metals (e.g., Ni-catalyzed asymmetric alcohol additions, Cu-phosphido transformations, and Ni-catalyzed cyano-ester and allene couplings). Efforts in these directions are focused on accessing organic structures that have been difficult to prepare by current asymmetric catalysis technologies, including chiral ethers, phosphines, and peptides. The mechanistic approach to these activities will help enable the participating graduate students to gain critical analysis and troubleshooting skills and will also engage undergraduate and high school students in chemical research at a fundamental level.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学催化计划的支持下，加州大学欧文分校的Vy Dong教授正在研究新催化反应的发展，以加快有机分子的合成，提高效率和减少浪费。地球丰富的镍催化剂将被研究用于C-O键和非天然氨基酸的构建，并精确控制三维分子形状。硒的引入到小分子和新的不对称膦配体的建设也将探索使用硒和铜催化。该项目旨在进一步了解如何建立具有挑战性的化学键，同时减少对贵金属的依赖。精确控制分子的形状对于优化和微调药物和材料的性能至关重要;因此，该提案正在创建分子构建工具，使其他领域的科学家能够设计未来的疗法和材料技术。预计这些活动将进一步为研究生、本科生和高中生研究人员提供培训。此外，董教授还积极倡导通过社交媒体让学生和公众参与化学讨论，并为化学界的女性树立榜样和增加交流机会。开发新的催化剂，使有机分子的对映选择性合成方法能够持续发展，这对于在药物、材料和生物探针制备方面取得持续进展至关重要。该计划的特点是催化策略，以解决现代合成的挑战。在该奖项下，董教授和她的研究团队将追求以下目标：（1）活化硫属元素用于氢官能化，（2）设计和构建膦，（3）锻造氨基酸和环肽的新路线。这三个主要目标的特征在于过渡金属催化剂，包括衍生自地球丰富的第一行金属的那些（例如，Ni催化的不对称醇加成、Cu-膦基转化和Ni催化的氰基酯和联烯偶联）。在这些方向上的努力集中在获得通过当前不对称催化技术难以制备的有机结构，包括手性醚、膦和肽。这些活动的机械方法将有助于使参与的研究生获得批判性分析和故障排除技能，也将使本科生和高中生参与基础水平的化学研究。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。