UNS: Density-based Biosensors

CBET - 1512686，Subramaniam，Anand B。该项目提议开发一种最近报告的技术，使用一种称为磁悬浮的方法来感测生物实体。 所提出的方法的主要优点之一是在电力和分析仪器不可用的环境中的应用。 传感器输出是可视的，因此对低资源设置有影响。该项目提议开发一种最近报告的技术，使用一种称为磁悬浮的方法来感测生物实体。 所提出的方法的主要优点之一是在电力和分析仪器不可用的环境中的应用。 传感器输出是可视的，因此对低资源设置有影响。 生物传感的方法使用密度的变化作为传感机制。所提出的研究集中于了解珠的形状和大小，以及纳米颗粒催化剂的大小对基于密度的生物传感器的性能的影响。将进行实验的数学建模并与实验数据进行比较，这一努力将允许在各种条件下在表面上无电生长纳米颗粒的过程中制定分析模型。更广泛的影响：拟议的研究将有助于教育和培训研究生和本科生在一个多样化的，多学科的环境。PI将与加州相对落后的中央谷地区的当地高中教师合作，传播关于低成本诊断和纳米科学的科学发现。PI计划在PI网站上以及通过期刊出版物和演示文稿传播结果。

CBET - 1512686, Subramaniam, Anand B. The project proposes to develop a recently reported technique for sensing of biological entities using a method known as magnetic levitation. One of the main advantages of the proposed method is application in environments where electricity and analytical instruments are not available. The sensor output is visual and thus impactful for low resource settings. The project proposes to develop a recently reported technique for sensing of biological entities using a method known as magnetic levitation. One of the main advantages of the proposed method is application in environments where electricity and analytical instruments are not available. The sensor output is visual and thus impactful for low resource settings. The approach for biosensing uses changes in the density as a sensing mechanism. The proposed studies are focused on understanding the effect of bead shape and size, and size of the nanoparticle catalysts on the performance of the density-based biosensor. Mathematical modeling of experiments will be conducted and compared with experimental data, and that effort will allow the formulation of analytical models on the process of electroless growth of nanoparticles on surfaces under various conditions. Broader Impact: The proposed research will contribute to the education and training of graduate and undergraduate students in a diverse, multidisciplinary environment. The PI will partner with local high school teachers in the relatively underserved Central Valley region of California to disseminate the scientific findings on low-cost diagnostics and nanoscience. The PI plans dissemination of results on the PI's website as well as through journal publications and presentations.