EAPSI: Inkjet Printed Paper-Based Chemical Sensor for Vitamin E

由于血液的复杂性质、总成本、时间和涉及的仪器，测量血液中维生素E的含量是很困难的。开发一种化学传感墨水，然后将其打印到纸上，这将是一种测定生物体液中维生素E水平的新方法。多年来，人们一直在家里和办公室使用喷墨打印；然而，它已经从办公室和家庭应用过渡到化学传感应用。现代喷墨打印机支持创建精确和非接触式沉积微观尺寸的液滴的化学传感器到纸上。该奖项支持将喷墨打印与分子印迹聚合物（MIPs）相结合的研究，以开发一种可用于测试体液中维生素E水平的新传感器。这项研究将与日本东京庆应义塾大学的Daniel Citterio博士合作进行，他是开发微流体纸基分析装置的喷墨打印技术专家。这一合作的结果将使点护理检测系统更加准确、精确、可重复，而且总体上比目前的血液检测方法更便宜。所提出的化学传感器将利用水性，非共价交联网络，MIP作为印刷在纸基基材上的油墨。必须克服的关键挑战是创造一种MIP，这种MIP既为水性，又对维生素E具有很强的选择性结合亲和力。MIP将被配制并打印到纸上，以便使用荧光响应指示器测量维生素E水平。Citterio博士吗?S组首次展示了使用喷墨打印通过基板的微流控图案沉积生化传感器的功能。作为一种新型的化学传感器，创造这样一种技术可以在许多不同的领域有多种用途。国家科学基金会EAPSI奖是与日本科学促进会合作资助的。

Measuring the amount of vitamin E present in blood is difficult because of the complex nature of blood, overall cost, amount of time, and instrumentation involved. The development of a chemical sensor ink, which is then printed onto paper, would be a novel approach to determining vitamin E levels in biological fluids. For years, people have been using ink jet printing in their homes and offices; however, it has transitioned from an office and home application to an application for chemical sensing. Modern inkjet printers support the creation of precise and contactless deposition of microscopic sized droplets of the chemical sensor onto paper. This award supports research that combines inkjet printing with molecular imprinted polymers (MIPs) to develop a new sensor that can be used to test levels of Vitamin E in bodily fluids. This research will be conducted in collaboration with Dr. Daniel Citterio at Keio University in Tokyo Japan, who is an expert in inkjet printing technology for the development of microfluidic paper-based analytical devises. Results from this collaboration could allow for a point of care testing system that would be accurate, precise, reproducible, and overall cheaper than current blood testing methods. The proposed chemical sensor would utilize an aqueous, non-covalently crosslinked network, MIP as an ink to be printed onto paper based substrates. The key challenge that must be overcome is creating an MIP that is both aqueous and presents a strong and selective binding affinity for vitamin E. MIP will be formulated and printed onto paper so that vitamin E levels can be measured using a fluorescence response indicator. Dr. Citterio?s group was the first to demonstrate the function of using ink jet printing for the deposition of biochemical sensors by microfluidic patterning of the substrates. Creating such a technology could have multiple uses in many different fields as a new class of chemical sensors. The NSF EAPSI award is funded in collaboration with the Japan Society for the Promotion of Science.