EAPSI: Development of a Vitamin C Sensor: Anchoring Aqueous Polymers to Glass Substrates

EAPSI：维生素 C 传感器的开发：将水性聚合物锚定到玻璃基板上

• 批准号: 1614240
• 负责人: Casey Grenier
• 金额: $ 0.54万
• 依托单位: Grenier Casey J
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1614240&HistoricalAwards=false
• 关键词: EAPSI; Development; Vitamin; Sensor; Anchoring

Measuring the amount of vitamin C present in blood is difficult because of the complex nature of blood, overall cost, amount of time, and instrumentation involved. The award supports research to synthesize a polymer sensing network and anchor it to the surface of a gold coated glass slide, forming a viable chemical sensor for testing levels of vitamin C in bodily fluids. This sensor array will be a reproducible and universally stable analytical tool that is capable of numerous other measurements: the analysis of bodily fluids, testing the cleanliness of water, and instantaneous monitoring of drug levels within the body. The development of these types of proposed sensors could enable point of care measurements for the medical community and the developing world. The research will be conducted in collaboration with Professor Wei-Ssu Liao of National Taiwan University in Taipei, Taiwan.The polymer sensor is formed by an aqueous molecularly imprinted polymer (MIP) network. Unlike most MIPs, which form polymer particles due to the high levels of rigid covalent bonds, our MIP is in liquid form because it utilizes less rigid non-covalent bonds to form its sensing network. In addition to being able to bind to the desired molecule (vitamin C), this MIP has a fluorescence response monomer unit within the network. This allows for a visual ?on/off? sensing of the desired molecule. This network is synthesized using a living polymerization technique, thus allowing the polymer solution to have functionalized end groups that can be reduced to bind to any gold surface. The MIP sensor is capable of rapid binding and high selectivity, and when anchored onto a substrate it will create a sensor array for easy and accurate detection of vitamin C. This award under the East Asia and Pacific Summer Institutes program supports summer research by a U.S. graduate student and is jointly funded by NSF and the Ministry of Science and Technology of Taiwan.

测量血液中维生素C的含量是困难的，因为血液的复杂性，总成本，时间量和所涉及的仪器。该奖项支持合成聚合物传感网络并将其锚在镀金载玻片表面的研究，形成一种可行的化学传感器，用于测试体液中维生素C的水平。这种传感器阵列将是一种可重复的、普遍稳定的分析工具，能够进行许多其他测量：体液分析、水的清洁度测试以及体内药物水平的即时监测。这些类型的拟议传感器的开发可以使医疗界和发展中国家的护理点测量成为可能。该研究将与台湾国立台湾大学的Wei-Ssu Liao教授合作进行。聚合物传感器由水分子印迹聚合物（MIP）网络形成。与大多数由于高水平的刚性共价键而形成聚合物颗粒的MIP不同，我们的MIP是液体形式的，因为它利用较低刚性的非共价键来形成其传感网络。除了能够与所需分子（维生素C）结合外，该MIP在网络内具有荧光响应单体单元。这样可以看到吗开/关？感测所需分子。该网络是使用活性聚合技术合成的，因此允许聚合物溶液具有可以被还原以结合到任何金表面的官能化端基。MIP传感器能够快速结合和高选择性，并且当锚定到基底上时，它将创建传感器阵列，用于简单和准确地检测维生素C。该奖项在东亚和太平洋夏季研究所计划下支持美国研究生的夏季研究，由NSF和台湾科技部共同资助。