Development of a new animal model to investigate the influence of the magnitude, frequency and duration of mechanical loading on the fracture healing outcome as a basis for the enhancement of numerical fracture healing simulations according to these load

骨折愈合过程受生物力学和生物学因素的影响。最重要的生物力学因素是骨折块间运动（IFM）。以前的动物实验不允许调查的影响，机械负荷对骨折愈合的结果方面的幅度，频率和持续时间。应在昆士兰州科技大学（布里斯班）健康和生物医学创新研究所开发一种新的动物模型，该模型允许根据上述负载特性良好控制机械负载。因此，应该有可能通过使用主动固定器和羊胫骨双截骨术，将IFM与肌肉骨骼负荷隔离开来。在过去的几年中，乌尔姆大学骨科研究和生物力学研究所开发了一种用于模拟骨折愈合过程的数值模型，该模型允许分析IFM对骨折愈合结果的影响。由于缺乏适当的体内数据，无法增强该数值模型以研究机械载荷对频率、持续时间和载荷循环次数的影响。该奖学金的目的是与布里斯班合作开发新的动物模型，最适合于在体内研究的影响，机械负荷对骨折愈合的结果和最适合于增强我们的数值骨折愈合模型。因此，应该使用布里斯班的实验可能性以及乌尔姆的数值知识。我们的数字骨折愈合模型的增强的特点是，新的动物模型的发展可以直接影响现场和所有的边界条件，从手术到牺牲的动物，可以详细分析。这对于正确模拟体内实验是强制性的。

The fracture healing process is influenced by biomechanical and biological factors. The most important biomechanical factor is the interfragmentary movement (IFM). Previous animal experiments did not allow to investigate the influence of mechanical loading on the fracture healing outcome with regard to magnitude, frequency and duration. A new animal model should be developed at the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, which allows well controlled mechanical loading with regard to the load characteristics mentioned above. Thereby, it should be possible to apply the IFM isolated from the musculoskeletal loads with the use of an active fixator and a double osteotomy at the sheep tibia. In the last years, a numerical model for the simulation of the fracture healing process was developed at the Institute of Orthopaedic Research and Biomechanics, Ulm University, which allows analyzing the influence of the IFM on the fracture healing outcome. Due to the lack of appropriate in vivo data, it was not possible to enhance this numerical model to investigate the influence of mechanical loading with regard to the frequency, duration and the number of load cycles.The aim of this scholarship is the development of the new animal model in cooperation with Brisbane, which is both, optimally suitable for in vivo investigations on the influence of mechanical loading on the fracture healing outcome AND optimally suitable for the enhancement of our numerical fracture healing model. Therefore, the experimental possibilities in Brisbane as well as the numerical know-how from Ulm should be used. The special feature for the enhancement of our numerical fracture healing model is that the development of the new animal model can directly be influenced on-site and that all boundary conditions, ranging from surgery to sacrifice of the animals, could be analyzed in detail. This is mandatory to simulate the in vivo experiments correctly.