MRI: Acquisition of a Multinuclear 500 MHz NMR Spectrometer

在主要研究仪器（MRI）、化学研究仪器（CRIF）和EPSCoR项目的支持下，来自田纳西理工大学的Jessie Carrick教授及其同事Daniel Swartling、Jeffrey Rice、William Carroll和Xuanzhi Zhan将获得一台配备宽带氮冷冷冻探针的500 MHz核磁共振光谱仪。该光谱仪将允许在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及允许对生物学相关物种进行研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。相对于标准的核磁共振探针，氮冷却探针将提供显著增加的灵敏度。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为本科生和研究生教学和研究的一个组成部分。新仪器将对化学系、化学工程系和跨学科环境科学项目的教师的研究、培训和教学工作产生重大而直接的影响。配备了样品转换器的可靠仪器的存在，将使更多的学生能够在教学实验室中使用光谱仪，而不是这所大学目前使用的旧的低场仪器。实验结果表明，该仪器将在大二的有机课程、高级分析实验室和高级有机光谱学课程中使用。将特别强调女性和其他在STEM领域历史上代表性不足的学生。该建议旨在加强各级的研究和教育，特别是在以下领域：(a)合成双-1,2,4-三嗪配体，包括模拟锕系元素的构象和随后的络合研究，用于潜在的废核燃料修复；(b)神经再生和伤口愈合荧光蛋白的结构特征；(c)发展动态分子的溶液相结构方法；(d)研究阻滞蛋白的构象；(e)发展绿色化学方法；(f)研究硫代氨基脲配体作为潜在的抗癌治疗药物。

With this award supported by the Major Research Instrumentation (MRI), the Chemistry Research Instrumentation (CRIF), and EPSCoR programs, Professor Jessie Carrick from Tennessee Technological University and colleagues Daniel Swartling, Jeffrey Rice, William Carroll and Xuanzhi Zhan will acquire a 500 MHz NMR spectrometer equipped with a broadband nitrogen-cooled cryoprobe. This spectrometer will allow research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe will provide a significant increase in sensitivity relative to standard NMR probes. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate and graduate students. The new instrument will have a significant and immediate impact on the research training and teaching endeavors of faculty in the departments of Chemistry as well as Chemical Engineering and an interdisciplinary Environmental Sciences Program. The presence of a reliable instrument equipped with a sample changer will allow much greater student access to a spectrometer in the teaching laboratories than an old, low-field instrument currently at this university. The PIs indicate that the instrument will be utilized by students in the sophomore organic courses, the advanced analytical laboratory, and an advanced organic spectroscopy course. Special emphasis will be directed to women and other historically underrepresented students in STEM.The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) synthesizing bis-1,2,4-triazine ligands, including conformational and subsequent complexation studies with simulated actinides for potential remediation of used nuclear fuel; (b) structurally characterizing fluorescent proteins for nerve regeneration and wound healing; (c) developing solution phase structure approaches for dynamic molecules; (d) studying conformations of arrestin proteins; (e) developing green chemistry methodology; and (f) studying thiosemicarbazone ligands as potential anti-cancer therapeutics.