MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer with a Multinuclear Probe and a Sample Changer

MRI：配备多核探针和样品更换器的 400 MHz 核磁共振波谱仪的采集

• 批准号: 1429308
• 负责人: Timothy Barker
• 金额: $ 31.98万
• 依托单位: College of Charleston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1429308&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Nuclear

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Justin Wyatt from the College of Charleston and colleagues Timothy Barker, Wendy Cory, Marcello Forconi and Brooke Van Horn will acquire a 400 MHz NMR spectrometer equipped with a multinuclear probe and a sample changer. This spectrometer will allow research in a variety of fields such as the study of biologically and environmentally relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate students at the College of Charleston and will involve the South Carolina Alliance for Minority Participation.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) confirmation of the structure of small molecule anticancer agents with improved sensitivity in 1D/2D NMR experiments; (b) analyzing conformational and structural features of small molecules containing silicon; (c) utilizing improved sensitivity to monitor polymerization kinetic experiments; (d) using NMR water suppression techniques to characterize the products of reactions between fluorobenzonitriles and cysteine in biological systems; (e) evaluating regiochemistry of hydroxymethylation products of derivatized hetereoaromatic compounds for drug development; and (f) characterization of pharmaceutical degradation products of environmental concern.

有了这项来自主要研究仪器计划（MRI）的奖项和化学研究仪器计划（CRIF）的支持，来自查尔斯顿学院的Justin Wyatt教授和同事Timothy Barker，Wendy Cory，Marcello Forconi和布鲁克范霍恩将获得一台配备多核探针和样品交换器的400 MHz NMR光谱仪。该光谱仪将允许在各种领域进行研究，例如生物和环境相关物种的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学的一个组成部分，也是查尔斯顿学院本科生进行的研究的一部分，并将涉及南卡罗来纳州少数民族参与联盟，该奖项旨在加强各级的研究和教育，特别是在以下领域：（a）确认小分子抗癌剂的结构，提高一维/二维核磁共振实验的灵敏度;（B）分析含硅小分子的构象和结构特征;（c）利用改进的灵敏度来监测聚合动力学实验;（d）使用NMR水抑制技术来表征生物系统中氟苯腈和半胱氨酸之间的反应产物;（e）评价用于药物开发的衍生化杂芳族化合物的羟甲基化产物的区域化学;和（f）表征与环境有关的药物降解产物。