MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance Spectrometer with a Multinuclear Probe and a Sample Changer

在重大研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，查尔斯顿学院的贾斯汀·怀亚特教授及其同事蒂莫西·巴克、温迪·科里、马塞洛·福尔科尼和布鲁克·范·霍恩将获得一台配备多核探头和样品转换器的400 MHz核磁共振光谱仪。这种光谱仪将允许在各种领域进行研究，例如研究与生物和环境相关的物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是查尔斯顿学院本科生教学和研究的一部分，并将与南卡罗来纳州少数民族参与联盟合作。该奖项旨在加强各级的研究和教育，特别是在以下领域：(A)在一维/二维核磁共振实验中确认具有更高灵敏度的小分子抗癌剂的结构；(B)分析含硅小分子的构象和结构特征；(C)利用改进的灵敏度来监测聚合动力学实验；(D)使用核磁共振水抑制技术表征生物体系中氟苯甲腈和半胱氨酸的反应产物；(E)评价用于药物开发的异芳烃衍生化合物羟甲基化产物的区域化学；和(F)对引起环境关注的药物降解产物进行表征。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Professor Justin Wyatt from the College of Charleston and colleagues Timothy Barker, Wendy Cory, Marcello Forconi and Brooke Van Horn will acquire a 400 MHz NMR spectrometer equipped with a multinuclear probe and a sample changer. This spectrometer will allow research in a variety of fields such as the study of biologically and environmentally relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research performed by undergraduate students at the College of Charleston and will involve the South Carolina Alliance for Minority Participation.The award is aimed at enhancing research and education at all levels, especially in areas such as (a) confirmation of the structure of small molecule anticancer agents with improved sensitivity in 1D/2D NMR experiments; (b) analyzing conformational and structural features of small molecules containing silicon; (c) utilizing improved sensitivity to monitor polymerization kinetic experiments; (d) using NMR water suppression techniques to characterize the products of reactions between fluorobenzonitriles and cysteine in biological systems; (e) evaluating regiochemistry of hydroxymethylation products of derivatized hetereoaromatic compounds for drug development; and (f) characterization of pharmaceutical degradation products of environmental concern.