PFI:BIC - A Smart, "Always-on" Health Monitoring System

这种创新伙伴关系：建设创新能力（PFI：BIC）项目旨在开发一个智能的、“永远在线”的健康监测系统，能够将医疗保健从被动的、以医院为中心转变为主动的、以证据为基础的、以个人为导向的、以人为本的。 特别是，该项目旨在克服移动可穿戴电子系统的使用问题，这些问题破坏了患者的长期接受度。 基于主要研究人员开发的“表皮”电子平台，该系统将提供“皮肤般”的特性，以当今任何技术都无法实现的方式与人进行亲密，完整，非侵入性的整合。 这种移动可穿戴健康监测系统将在机械上“不可见”（即，不限制皮肤的自然运动或过程），并且将与日常生活活动相容以确保用户的长期持续参与。 它将通过自我检测、自我诊断和自我监测与人互动，并允许临床医生通过无线通信和数据传输监测患者，以促进自我纠正和自我控制功能。它将使公众能够不断评估个人健康和福祉。 对医疗设备的持续监测有助于通过早期干预预防严重的医疗问题，特别是在高危人群中，从而为医疗保健服务系统提供关键能力。在追求促进具有无线连接到监测和诊断系统的柔性皮肤应用传感器的开发和成熟的基本目标时，该项目结合了主要研究人员在拟议平台核心知识内容方面的研究专长，其中包括纳米材料、传感器、先进信号处理、系统设计、工业设计/人为因素和临床研究。 这种整合将导致智能系统有可能改变医疗保健。 这项研究包括以下内容： * 开发具有无线操作功能的“类皮肤”温度、水化和电生理传感器。 这些系统将利用独特的硬件，由主要研究人员最近在表皮电子和传感器方面的工作扩展而成。 * 研究这种技术与人之间的相互作用，特别是为了考虑与技术发展相关的人为因素，以确保生活方式的兼容性。 * 为传感器数据的统计信号处理和模式识别开发有效和强大的计算建模和算法，为临床医生，患者甚至公众创建用户友好的界面，以便解释这些数据及其对健康和福祉的影响。 * 将所提出的健康监测系统应用于皮肤。 传感器数据的持续捕获、存储和传输对于这些智能的、“永远在线”的健康监测系统的设计至关重要。可穿戴设备的机械“隐形”意味着它们不会干扰人们的日常生活。 生活方式兼容性的解释可以如下所示：一个设备为了简单地佩戴它而需要的行为改变越少，它就越有可能推动用户的长期持续参与，从而克服大多数可穿戴设备的主要局限性。本研究开始时的主要合作伙伴包括牵头机构：西北大学、麦考密克工程学院和范伯格医学院; MC 10公司（剑桥，马萨诸塞州，小企业）;伊利诺伊大学厄巴纳-尚潘分校（尚潘，伊利诺伊州，非营利，教育）。

This Partnerships for Innovation: Building Innovation Capacity (PFI:BIC) project aims to develop a smart, "always-on" health-monitoring system capable of transforming healthcare from reactive and hospital-centered to proactive, evidence-based, individual-oriented and human-centered. In particular, the project seeks to overcome use problems with mobile-wearable electronics systems that have undermined long-term patient acceptance. Based on the "epidermal" electronic platform developed by the principal investigators, the system will offer "skin-like" properties, to enable intimate, complete, non-invasive integration with people in ways that are impossible with any technology that exists today. This mobile-wearable health-monitoring system will be mechanically "invisible" (i.e., not constraining natural motions or processes of the skin), and will be compatible with daily life activities to ensure long-term sustained engagement of users. It will interact with people through self-detection, self-diagnosis and self-monitoring and will allow clinicians to monitor their patients through wireless communications and data transmission to facilitate self-correcting and self-controlled functions. It will allow the general public to continuously assess personal health and well-being. Continuous monitoring of medical devices may help to prevent serious medical problems through early intervention, particularly in high risk groups of people, thereby providing critical capabilities to the healthcare service system.In pursuing the basic goal of spurring the development and maturation of flexible skin-applied sensors with wireless connection to monitoring and diagnostic systems, the project combines the research expertise of the principal investigators in the core intellectual content of the proposed platforms, which includes nanomaterials, sensors, advanced signal processing, system design, industrial design/human factors and clinical studies. This integration will lead to smart systems that have the potential to transform healthcare. The research entails the following: * Development of "skin-like" temperature, hydration, and electrophysiology sensors, with wireless operation. These systems will exploit unique hardware, formed using extensions of ideas from the principal investigators' recent work on epidermal electronics and sensors. * Studies of interactions between this technology and people, particularly in order to account for human factors relevant to the technology development to ensure lifestyle compatibility. * Development of effective and robust computational modeling and algorithms for statistical signal processing of the sensor data and pattern recognition to create a user-friendly interface for clinicians, patients and even the general public to enable the interpretation of these data and their implications for health and well-being. * Application of the proposed health monitoring system to skin. The continuous capture, storage and transmission of sensor data will be critical to the design of these smart, "always-on" health-monitoring systems.The mechanical "invisibility" of the wearable devices means that they do not interfere with people's daily lives. Accounting for lifestyle compatibility can be illustrated as follows: the less behavior change a device requires in order to simply wear it, the more likely it is that it will drive long-term sustained engagement for users and thus overcome the major limitation of most wearable devices.The primary partners at the inception of this research include the Lead Institution: Northwestern University, McCormick School of Engineering and Feinberg School of Medicine; MC10, Inc (Cambridge, Massachusetts, small business); and University of Illinois at Urbana-Champaign (Champaign, Illinois, non-profit, educational).